1150586-64-3

Basic information

• Product Name: CB-86
• Synonyms: CB-86
• CAS NO: 1150586-64-3
• Molecular Formula: C₂₆H₄₃NO₃
• Molecular Weight: 417.62452
• Mol File: 1150586-64-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CB-86(CAS DataBase Reference)
• NIST Chemistry Reference: CB-86(1150586-64-3)
• EPA Substance Registry System: CB-86(1150586-64-3)

Safety Data

• Hazardous Substances Data: 1150586-64-3(Hazardous Substances Data)

Usage

Description

CB-86 is a synthetic chemical compound belonging to the phenylpropanoid class. It serves as a selective antagonist of the GABA receptor, blocking GABA's action at its receptor sites, making it a valuable tool for studying GABAergic activity in the nervous system and its role in physiological processes.

Uses

Used in Pharmaceutical Research:
CB-86 is used as a chemical tool for studying the activity of the neurotransmitter GABA in the nervous system, aiding in understanding the role of GABA receptors in various physiological processes.
Used in Neurological Conditions Research:
CB-86 is used as a potential treatment for conditions such as anxiety and epilepsy, due to its ability to modulate GABAergic activity in the brain, offering insights into the development of therapeutic interventions for these conditions.

Upstream product

• 1150586-50-7 8-[5-(2-methyloctan-2-yl)phenoxy]octanoic acid 
• 765-30-0 Cyclopropylamine 

Relevant articles and documents

New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo

Bearing in mind the pharmacophoric requirements of both (-)-trans-Δ9-tetrahydrocannabinol (THC) and anandamide (AEA), we designed a novel pharmacophore consisting of both a rigid aromatic backbone and a flexible chain with the aim to develop a series of stable and potent ligands of cannabinoid receptors. In this paper we report the synthesis, docking studies, and structure-activity relationships of new resorcinol-anandamide "hybrids" differing in the side chain group. Compounds bearing a 2-methyloctan-2-yl group at position 5 showed a significantly higher affinity for cannabinoid (CB) receptors, in particular when an alkyloxy chain of 7 or 10 carbon atoms was also present at position 1. Derivative 32 was a potent CB 1 and CB2 ligand, with Ki values similar to that of WIN 55-212 and potent antinociceptive activity in vivo. Moreover, derivative 38, although less potent, proved to be the most selective ligand for CB2 receptor (Ki(CB1)) 1 μM, K i(CB2)) 35 nM).