1150617-61-0

Basic information

• Product Name: 5-chloro-2-iodo-1-Methyl-3-nitrobenzene
• Synonyms: 5-Chloro-2-iodo-3-methylnitrobenzene;5-chloro-2-iodo-1-Methyl-3-nitrobenzene;Benzene, 5-chloro-2-iodo-1-methyl-3-nitro-
• CAS NO: 1150617-61-0
• Molecular Formula: C₇H₅ClINO₂
• Molecular Weight: 297.47757
• Mol File: 1150617-61-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 322.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.962±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-chloro-2-iodo-1-Methyl-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-iodo-1-Methyl-3-nitrobenzene(1150617-61-0)
• EPA Substance Registry System: 5-chloro-2-iodo-1-Methyl-3-nitrobenzene(1150617-61-0)

Safety Data

• Hazardous Substances Data: 1150617-61-0(Hazardous Substances Data)

Usage

General Description

5-chloro-2-iodo-1-methyl-3-nitrobenzene is a chemical compound with the molecular formula C7H6ClINO2. It is a derivative of benzene, containing a chlorine, iodine, methyl, and nitro functional group. 5-chloro-2-iodo-1-Methyl-3-nitrobenzene is commonly used in organic synthesis and pharmaceutical research as a building block for the production of various drugs and active pharmaceutical ingredients. It is also used as a reagent in chemical reactions to introduce specific functional groups into organic molecules. Additionally, it has potential applications in the field of agrochemicals and material science. Due to its unique chemical structure, 5-chloro-2-iodo-1-methyl-3-nitrobenzene exhibits specific properties that make it valuable for various industrial and scientific purposes.

Upstream product

• 570-24-1 2-Methyl-6-nitroaniline 
• 62790-50-5 4-chloro-2-methyl-6-nitrophenylamine 

Downstream Products

• 1150617-63-2 5-chloro-2-iodo-3-methylphenylamine 
• 1150617-66-5 5-chloro-2-iodo-3-methylphenol 
• 1150617-68-7 5-chloro-2-iodo-1-methoxy-3-methylbenzene 
• 1207961-49-6 2-(4-chloro-2-methoxy-6-methylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane 
• 1207961-32-7 2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide 
• 1207961-33-8 2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoropropyl)amide 
• 1207961-48-5 2-amino-4-(4-chloro-2-hydroxy-6-methylphenyl)-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester 
• 1207961-61-2 2-amino-4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester 
• 1207961-60-1 4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine 
• 1207961-50-9 4-chloro-2-hydroxy-6-methylphenylboronic acid 

Relevant articles and documents

Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h- pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5, 7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide

Figure Presented. A novel class of heat shock protein 90 (Hsp90) inhibitors was discovered by high-throughput screening and was subsequently optimized using a combination of structure-based design, parallel synthesis, and the application of medicinal chemistry principles. Through this process, the biochemical and cell-based potency of the original HTS lead were substantially improved along with the corresponding metabolic stability properties. These efforts culminated with the identification of a development candidate (compound 42) which displayed desired PK/PD relationships, significant efficacy in a melanoma A2058 xenograft tumor model, and attractive DMPK profiles.