115066-14-3 Usage
Description
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE, commonly known as CNQX, is a potent and selective non-NMDA glutamate receptor antagonist. It is a pale yellow solid with a chemical structure that allows it to competitively inhibit AMPA and kainate receptors, making it a valuable tool in neuroscience research.
Uses
Used in Neuroscience Research:
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE is used as a competitive non-NMDA receptor antagonist for studying the role of glutamate receptors in neuronal cultures. It helps researchers differentiate the effects of AMPA and kainate receptors from those of NMDA receptors, providing valuable insights into the underlying mechanisms of various neurological processes.
Used in Neurophysiology:
In neurophysiology, 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE is used as a glutamatergic blocker for measuring inhibitory postsynaptic currents in projection neurons. This allows researchers to investigate the interactions between neurons and understand the role of glutamate in synaptic transmission.
Used in Prefrontal Cortex Neuron Studies:
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE is employed as an AMPA glutamate receptor antagonist in prefrontal cortex neurons. This application helps researchers explore the functions of AMPA receptors in the prefrontal cortex, which is crucial for higher cognitive functions such as decision-making, attention, and working memory.
Used in Drug Development:
As a potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist, 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE has potential applications in the development of drugs targeting glutamate receptors. Its ability to selectively inhibit AMPA and kainate receptors makes it a promising candidate for the treatment of neurological disorders associated with glutamate receptor dysfunction, such as epilepsy, stroke, and neurodegenerative diseases.
Biological Activity
Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.
Biochem/physiol Actions
Potent, competitive AMPA/kainate glutamate receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 115066-14-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,0,6 and 6 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 115066-14:
(8*1)+(7*1)+(6*5)+(5*0)+(4*6)+(3*6)+(2*1)+(1*4)=93
93 % 10 = 3
So 115066-14-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H2N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H
