1150883-75-2 Usage
Description
(αS,2S,3R)-5-Carboxy-4-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-3,4-dihydro-α-[(1R)-1-hydroxyethyl]-3-methyl-2H-pyrrole-2-acetic Acid is a complex organic compound with a unique molecular structure. It is characterized by its stereochemistry, which is essential for its potential applications and interactions with other molecules.
Uses
Used in Pharmaceutical Industry:
(αS,2S,3R)-5-Carboxy-4-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-3,4-dihydro-α-[(1R)-1-hydroxyethyl]-3-methyl-2H-pyrrole-2-acetic Acid is used as an impurity in the production of Ertapenem (E635000) for the pharmaceutical industry. Ertapenem is a broad-spectrum antibiotic used to treat various bacterial infections. The presence of this compound as an impurity may affect the efficacy, safety, or quality of the final product, making it crucial to monitor and control its levels during the manufacturing process.
Check Digit Verification of cas no
The CAS Registry Mumber 1150883-75-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,0,8,8 and 3 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1150883-75:
(9*1)+(8*1)+(7*5)+(6*0)+(5*8)+(4*8)+(3*3)+(2*7)+(1*5)=152
152 % 10 = 2
So 1150883-75-2 is a valid CAS Registry Number.
1150883-75-2Relevant articles and documents
A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation
Lohans, Christopher T.,van Groesen, Emma,Kumar, Kiran,Tooke, Catherine L.,Spencer, James,Paton, Robert S.,Brem, Jürgen,Schofield, Christopher J.
, p. 1282 - 1285 (2018)
β-Lactamases threaten the clinical use of carbapenems, which are considered antibiotics of last resort. The classical mechanism of serine carbapenemase catalysis proceeds through hydrolysis of an acyl-enzyme intermediate. We show that class D β-lactamases also degrade clinically used 1β-methyl-substituted carbapenems through the unprecedented formation of a carbapenem-derived β-lactone. β-Lactone formation results from nucleophilic attack of the carbapenem hydroxyethyl side chain on the ester carbonyl of the acyl-enzyme intermediate. The carbapenem-derived lactone products inhibit both serine β-lactamases (particularly class D) and metallo-β-lactamases. These results define a new mechanism for the class D carbapenemases, in which a hydrolytic water molecule is not required.