115098-06-1

Basic information

• Product Name: 1,3-bis-[4-(4-chloro-phenyl)-piperazino]-propane
• CAS NO: 115098-06-1
• Molecular Weight: 433.424
• Mol File: 115098-06-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-bis-[4-(4-chloro-phenyl)-piperazino]-propane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis-[4-(4-chloro-phenyl)-piperazino]-propane(115098-06-1)
• EPA Substance Registry System: 1,3-bis-[4-(4-chloro-phenyl)-piperazino]-propane(115098-06-1)

Safety Data

• Hazardous Substances Data: 115098-06-1(Hazardous Substances Data)

Upstream product

• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 109-70-6 1.3-chlorobromopropane 

Relevant articles and documents

Synthesis of new 1,2,3-benzotriazin-4-one-arylpiperazine derivatives as 5-HT(1A) serotonin receptor ligands

A series of novel 1,2,3-benzotriazin-4-one derivatives was prepared and evaluated as ligands for 5-HT receptors. Radioligand binding assays proved that the majority of the novel compounds behaved as good to excellent ligands at the 5-HT(1A) receptor, some of which were selective with respect 5-HT(2A) and 5-HT(2C) receptors. Six analogues (1a, 2a, 2b, 2c, 2e and 2i) were selected and further evaluated for their binding affinities on D1, D2 dopaminergic and α1-, α2-adrenergic receptors. A o-OCH3 derivative (2e) bound at 5-HT(1A) sites with subnanomolar affinity (IC50=0.059 nM) and shows high selectivity over all considered receptors and may offer a new lead for the development of therapeutically efficacious agents. Copyright (C) 2000 Elsevier Science Ltd.