115104-28-4 Usage
Description
(E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT is a complex organic compound with a unique chemical structure. It is characterized by its yellow solid appearance and is known for its receptor antagonist properties, specifically targeting the CysLT1 receptor. (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT plays a crucial role in the treatment of respiratory diseases, such as asthma, by blocking the binding of LTD4 to human and guinea pig lung membranes.
Uses
1. Used in Pharmaceutical Industry:
(E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT is used as a receptor antagonist for the treatment of respiratory diseases. It effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors, which is crucial in managing asthma symptoms and improving the bronchoalveolar lavage fluid proteome.
2. Used in Research and Development:
In addition to its pharmaceutical applications, (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT can be utilized in research and development for further understanding of its receptor antagonist properties and potential applications in other therapeutic areas.
3. Used in Drug Delivery Systems:
Similar to gallotannin, (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT may benefit from novel drug delivery systems to enhance its efficacy and bioavailability. These systems could include organic and metallic nanoparticles as carriers, aiming to improve the compound's delivery and therapeutic outcomes in the treatment of respiratory diseases.
Biological Activity
Potent CysLT 1 (LTD 4 ) leukotriene receptor inverse agonist (EC 50 = 1.3 nM). Antagonizes LTD 4 -induced contractions of guinea pig trachea and ileum (pA 2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.
References
1) Jones et al. (1989) Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.; Can. J. Physiol. Pharmacol. 67, 17
2) Dupre et al. (2004) Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1; J. Pharmacol. Exp. Ther. 309 102
3) Vellenga et al. (1999) Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1; Br .J. Pharmacol. 127 441
Check Digit Verification of cas no
The CAS Registry Mumber 115104-28-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,1,0 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 115104-28:
(8*1)+(7*1)+(6*5)+(5*1)+(4*0)+(3*4)+(2*2)+(1*8)=74
74 % 10 = 4
So 115104-28-4 is a valid CAS Registry Number.
InChI:InChI=1/C26H27ClN2O3S2.Na/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22;/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32);/q;+1/p-1/b10-6+;
115104-28-4Relevant articles and documents
ASYMMETRIC DITHIOACETALS III: THE PREPARATION OF THE ENANTIOMERS OF 3-((((3-(2-(7-CHLOROQUINOLIN-2-YL)-(E)-ETHENYL)PHENYL)-3-DIMETHYLAMINO-3-OXOPROPYLTHIO)METHYL)THIO)PROPIONIC ACID (L-660,711) (MK-571), AN ANTAGONIST OF LEUKOTRIENE D4
Young, Robert N.,Gauthier, Jacques Yves,Therien, Michel,Zamboni, Robert
, p. 967 - 978 (2007/10/02)
The application of a novel method for the preparation of chiral dithioacetals to the synthesis of the enantiomers of L-660,711, an antagonist of leukotriene D4, is described.Reaction of 3-(t-butyldiphenylsilyloxymethyl)benzaldehyde or isophthal
