115207-00-6Relevant articles and documents
Synthesis of Diastereomerically Pure 2,5-Disubstituted 3-Oxoperhydro-1,4-oxazines
Danklmaier, Johann,Hoenig, Helmut
, p. 851 - 854 (2007/10/02)
The syntheses of hitherto unknown, diastereomerically pure 2,5-disubstituted 3-oxoperhydro-1,4-oxazines ("3-morpholinones") are described.The conventional preparation of 3-morpholinones by direct condensation of sodium aminoalcoholates with esters of α-halogenocarboxylic acids is complemented by an alternative and milder two-step synthetic strategy.The methyl and hydroxyalkyl derivatives are characterized by their NMR-spectroscopical and optical data.