115220-56-9Relevant articles and documents
Free-radical reaction of imine derivatives in water
Miyabe, Hideto,Ueda, Masafumi,Naito, Takeaki
, p. 5043 - 5047 (2000)
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α-N-HYDROXYAMINO ACID DERIVATIVES
Kolasa, Teodozyj,Sharma, Sushil K.,Miller, Marvin J.
, p. 5431 - 5440 (2007/10/02)
Reactions of organolithium reagents with glyoxylate derived oximes provided a direct route to α-N-hydroxyamino acids.The process required direct attachment of an ionizable group to the glyoxylate carbonyl to prevent competitive reactions.The procedure allowed for direct formation of the α-chiral center of the newly formed α-N-hydroxyamino acid derivative.Introduction of potential chiral auxiliaries on the oxime oxygen resulted in modest diastereoselection.In most instances, use of chiral glyoxylamides also gave low diastereoselectivity.