1152749-21-7

Basic information

• Product Name: morpholino(1H-pyrazol-4-yl)methanone
• Synonyms: morpholino(1H-pyrazol-4-yl)methanone
• CAS NO: 1152749-21-7
• Molecular Weight: 181.194
• Mol File: 1152749-21-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: morpholino(1H-pyrazol-4-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: morpholino(1H-pyrazol-4-yl)methanone(1152749-21-7)
• EPA Substance Registry System: morpholino(1H-pyrazol-4-yl)methanone(1152749-21-7)

Safety Data

• Hazardous Substances Data: 1152749-21-7(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 37622-90-5 4-ethoxycarbonylpyrazole 
• 103286-53-9 1H-pyrazole-4-carboxylic acid chloride 
• 37718-11-9 1H-pyrazole-4-carboxylic acid 

Downstream Products

• 1152747-82-4 enerisant 
• 1152748-91-8 [1-(3-fluoro-4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-1H-pyrazol-4-yl](morpholin-4-yl)methanone 

Relevant articles and documents

METHOD OF PRODUCING CRYSTAL OF [1-(4-{3-[(2R)-2-METHYLPYRROLIDIN-1-YL]PROPOXY}PHENYL)-1H-PYRAZOL-4-YL](MORPHOLIN-4-YL)METHANONE

PROBLEM TO BE SOLVED: To provide a novel method of producing a crystal of [1-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-1H-pyrazol-4-yl](morpholin-4-yl)methanone, which exhibits H3 receptor antagonism. SOLUTION: The invention provides a method of producing a crystal of a compound represented by formula [1] in the figure, which is crystallized using an ether based solvent. (X1 is methanesulfonyloxy, trifluoromethanesulfonyloxy, or p-toluenesulfonyloxy; and X2 is a halogen atom.) SELECTED DRAWING: Figure 9 COPYRIGHT: (C)2019,JPOandINPIT

PHENYLPYRAZOLE DERIVATIVES

The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea sy