115319-76-1Relevant articles and documents
Total Synthesis of Avrainvilleol
Wegener, Aaron,Miller, Kenneth A.
, p. 11655 - 11658 (2017/11/10)
The first total synthesis of the marine natural product avrainvilleol is reported. The total synthesis features the first application of the transition-metal-free coupling of a tosyl hydrazone and a boronic acid to the preparation of a complex natural product, and the first example of this coupling with a hindered diortho substituted hydrazone substrate.
ON THE METALATION OF PHENOLIC COMPOUNDS: READY ACCESS TO HIGHLY SUBSTITUTED PHENOLS.
Costa, Antonio,Saa, Jose M.
, p. 5551 - 5554 (2007/10/02)
The direct metalation of several p-hydroxybenzylmethyl ethers has been studied.Those substrates possesing an electron-withdrawing group in a 1,3 relationship with the coordinating (-CH2OMe) group underwent regioselective metalation by the action of n-BuLi/THF.Highly substituted phenols can thus be readily prepared.