1153283-14-7

Basic information

• Product Name: C₁₃H₁₂BrN₃O
• Synonyms: C₁₃H₁₂BrN₃O
• CAS NO: 1153283-14-7
• Molecular Weight: 306.162
• Mol File: 1153283-14-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₂BrN₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₂BrN₃O(1153283-14-7)
• EPA Substance Registry System: C₁₃H₁₂BrN₃O(1153283-14-7)

Safety Data

• Hazardous Substances Data: 1153283-14-7(Hazardous Substances Data)

Upstream product

• 23138-55-8 3-Bromophenyl isocyanate 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 1428133-08-7 C₂₀H₁₅BrN₄O₃S 

Relevant articles and documents

Synthesis and in vitro antiproliferative activity of novel pyrazolo[3,4-d]pyrimidine derivatives

A novel series of pyrazolo[3,4-d]pyrimidine derivatives were designed, synthesized and evaluated for their antiproliferative activity. Among the five compounds selected by NCI, compound 11a showed a distinctive pattern of selectivity on cell line panels and was further screened for a 5-log dose range, where it showed potent antiproliferative activity with median growth inhibition (GI50) equal to 1.71 μM against the CNS cancer SNB-75 cell line. The tested derivative showed remarkably the highest cell growth inhibition against non-small cell lung cancer HOP-62, CNS cancer SNB-75, breast cancer HS578T, and melanoma MALME-3M cell lines. Flow cytometric analysis revealed that compound 11a could significantly induce apoptosis in A549 cells in vitro at low micromolar concentrations. Further investigation showed that compound 11a induced significant cell cycle arrest at G0/G1 phase partly due to its ability to downregulate cyclin D1 and upregulate p27kip1 levels.