115363-45-6

Basic information

• Product Name: N²-benzoyl-O⁶-(p-nitrophenylethyl)-2',3',5'-tris-O-(tert-butyldimethylsilyl)guanosine
• Synonyms: N²-benzoyl-O⁶-(p-nitrophenylethyl)-2',3',5'-tris-O-(tert-butyldimethylsilyl)guanosine
• CAS NO: 115363-45-6
• Molecular Weight: 879.289
• Mol File: 115363-45-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N²-benzoyl-O⁶-(p-nitrophenylethyl)-2',3',5'-tris-O-(tert-butyldimethylsilyl)guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-benzoyl-O⁶-(p-nitrophenylethyl)-2',3',5'-tris-O-(tert-butyldimethylsilyl)guanosine(115363-45-6)
• EPA Substance Registry System: N²-benzoyl-O⁶-(p-nitrophenylethyl)-2',3',5'-tris-O-(tert-butyldimethylsilyl)guanosine(115363-45-6)

Safety Data

• Hazardous Substances Data: 115363-45-6(Hazardous Substances Data)

Upstream product

• 72429-33-5 N²-Benzoyl-2',3',5'-tris-O-(tert-butyldimethylsilyl)guanosin 
• 100-27-6 2-(4-nitrophenyl)ethanol 

Downstream Products

• 115363-46-7 N²-benzoyl-O⁶-(p-nitrophenylethyl)-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 
• 115363-51-4 N²-benzoyl-O⁶-(p-nitrophenylethyl)-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(β-cyanoethyl N,N-diisopropylphosphoramidite) 
• 102302-25-0 N²-benzoyl-O⁶-(p-nitrophenylethyl)-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite) 

Relevant articles and documents

Synthesis and Spectroscopic Analysis of Branched RNA Fragments: Messenger RNA Splicing Intermediates

RNA splicing is now established as a major RNA processing reaction in eukaryotic cells.Splicing of messenger RNA precursors generates a lariat RNA structure containing a branched RNA core (Wallace J.C.; Edmons M.Proc.Natl.Acad.Sci.U.S.A. 1983, 80, 950-954) of the type A(2'p5'G)3'p5'X (AGX), where X is a pyrimidine residue.Understanding the mechanism which generates these molecules as well as the role they play in the splicing reaction are central issues in cell biology.Chemically synthesized branched RNA fragments of defined sequence and structure are likely to play a key role in understanding the full biological role of these molecules.Herein we describe the chemical synthesis of a series of trinucleotides (AUU, AGG, ACC, AGU, AUG, AGC, ACG, ATT, GUU, aAUU) and a tetranucleotide (UpAUU) with branched linkages.These molecules were fully characterized by UV, NMR (1H, 13C, 31P), HPLC analyses of enzymatic digests, and gel electrophoresis.