1154-09-2

Basic information

• Product Name: northiaden
• Synonyms: northiaden;11-(3-Methylaminopropylidene)-6,11-dihydrodibenz[b,e]thiepine;3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N-methyl-1-propanamine;Nordosulepin;Nordothiepin;Northiadene;3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N-Methyl-
• CAS NO: 1154-09-2
• Molecular Formula: C18H19NS
• Molecular Weight: 281.4152
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 1154-09-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 72-75°C
• Boiling Point: 438.5°Cat760mmHg
• Flash Point: 219°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 6.9E-08mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: northiaden(CAS DataBase Reference)
• NIST Chemistry Reference: northiaden(1154-09-2)
• EPA Substance Registry System: northiaden(1154-09-2)

Safety Data

• Hazardous Substances Data: 1154-09-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

A metabolite of Dothiepin.

InChI:InChI=1/C18H19NS.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10-;

Upstream product

• 2025-60-7 11-<3-(Methyl-ethoxycarbonylamino)-propyliden>-6,11-dihydro-dibenzothiepin 
• 897-15-4 dothiepin hydrochloride 

Relevant articles and documents

Study on zwitter-ionization of drugs. II. Synthesis and pharmacological activity of some N-[3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl]-N- methylamino- and N-[3-(6H-dibenz[b,e]oxepin-11-ylidene)propyl]-N-methylamino- alkanoic acid derivatives and related compounds

A series of N-[3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl]-N- methylamino- (6a) and N-[3-(6H-dibenz-[b,e]oxepin-11-ylidene)propyl]-N- methylamino-alkanoic acid derivatives (6b) and related compounds (6c-f) were synthesized and examined for pharmacological activities in vitro, i.e., inhibitory effect on monoamine [noradrenaline (NA) and 5-hydroxytryptamine (5-HT)] uptake, inhibitory effect on 5-HT-, histamine-, acetylcholine- and NA-induced contraction, and binding affinity for α2-adrenoceptor and dopamine D2-receptor. In vitro tests indicated that zwitter-ionization was capable of maintaining H1-antihistaminic activity while greatly reducing other pharmacological activities. Further, 6a-f showed much stronger inhibitory effects on compound 48/80-induced lethality in rats than did the corresponding N,N-dimethylamines (2a-f). 3-[N-[3-(6H-Dibenz[b,e]oxepin-11- ylidene)propyl]-N-methylamino]-propionic acid (6b-2), selected as a candidate antiallergic agent of a new type, equally potent in rats and guinea-pigs, exhibited strong inhibitory effects on 48 h homologous passive cutaneous anaphylaxis (PCA) in rats (ED50=0.019 mg/kg, p.o.) and on histamine- induced bronchoconstriction in anesthetized guinea-pigs (ED50=0.0067 mg/kg, p.o.).