115531-70-9 Usage
Description
(S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol is a chiral chemical compound with the molecular formula C8H17NO. It is a derivative of pyrrolidine, featuring a hydroxyl group, an amino group, and an ethyl group attached to a four-membered ring structure. (S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol is known for its biological activity, with only the (S)-enantiomer exhibiting such properties. Its unique structure and pharmacological potential make it a subject of interest for medicinal chemistry research, particularly in the development of drugs aimed at the central nervous system.
Uses
Used in Pharmaceutical Industry:
(S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol is used as a key compound for the development of drugs targeting the central nervous system due to its potential pharmacological properties and biological activity. Its unique structure allows for the creation of novel therapeutic agents that can potentially address various neurological conditions and disorders.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol serves as a valuable starting point for the synthesis of new drug candidates. Its chiral nature and the presence of functional groups make it an ideal candidate for further modification and optimization to enhance its pharmacological properties and improve its therapeutic potential.
Used in Drug Design and Development:
(S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol is utilized in drug design and development as a structural template for creating new molecules with enhanced efficacy and selectivity. Its unique combination of a hydroxyl group, an amino group, and an ethyl group attached to a four-membered ring structure provides a versatile platform for the development of innovative therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 115531-70-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,5,3 and 1 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 115531-70:
(8*1)+(7*1)+(6*5)+(5*5)+(4*3)+(3*1)+(2*7)+(1*0)=99
99 % 10 = 9
So 115531-70-9 is a valid CAS Registry Number.
115531-70-9Relevant articles and documents
Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation
Fournier-Dit-Chabert, Jérémie,Vinader, Victoria,Santos, Ana Rita,Redondo-Horcajo, Mariano,Dreneau, Aurore,Basak, Ramkrishna,Cosentino, Laura,Marston, Gemma,Abdel-Rahman, Hamdy,Loadman, Paul M.,Shnyder, Steven D.,Díaz, José Fernando,Barasoain, Isabel,Falconer, Robert A.,Pors, Klaus
, p. 7693 - 7696 (2012)
Colchicine was modified at the 10-OCH3 position of the C-ring by reaction with heterocyclic amines or commercially available amines to afford a library of target colchicinoids in high yields (62-99%). Molecular modeling revealed that the incorporation of the linker groups led to a reduction in entropy and therefore binding affinity when compared with colchicine. Some colchicinoids were shown to be equicytotoxic with colchicine when evaluated in the DLD-1 colon cancer cells and retained activity in resistant A2780AD or HeLa cells with mutant Class III β-tubulin. Importantly, unlike colchicine, the analogues in this study are amenable for prodrug derivatisation and with potential for tumor-selective delivery.
Pyrrolidin-2-one derivatives having nootropic activity
-
, (2008/06/13)
Pyrrolidin-2-one derivatives of formula I: STR1 wherein X=H, OH, C2 -C7 acyloxy, C1 -C6 alkoxy, cycloalkoxy or phenoxy, n=0 or 1 and m=2 or 3, have a marked nootropic activity.
