1155361-09-3 Usage
Description
Cytochrome P450 14a-demethylase inhibitor 1k is a chemical compound that functions as an inhibitor of the enzyme cytochrome P450 14a-demethylase. This enzyme plays a crucial role in the metabolism of various compounds, including the conversion of lanosterol to ergosterol in fungi. The inhibitory action of this compound on the enzyme makes it a promising candidate for antifungal applications and as a tool in medical research for studying the role of cytochrome P450 enzymes in drug metabolism and toxicology.
Uses
Used in Antifungal Applications:
Cytochrome P450 14a-demethylase inhibitor 1k is used as an antifungal agent for targeting the enzyme cytochrome P450 14a-demethylase, which is involved in the conversion of lanosterol to ergosterol in fungi. By inhibiting this enzyme, the compound can disrupt the fungal cell membrane synthesis and growth, making it a potential candidate for the development of new antifungal therapies.
Used in Medical Research:
Cytochrome P450 14a-demethylase inhibitor 1k is used as a research tool for studying the role of cytochrome P450 enzymes in drug metabolism and toxicology. CytochroMe P450 14a-deMethylase inhibitor 1k's ability to inhibit the enzyme cytochrome P450 14a-demethylase allows researchers to investigate the enzyme's function and its involvement in various biological processes, which can contribute to a better understanding of drug interactions and potential drug toxicity.
Used in Drug Development:
Cytochrome P450 14a-demethylase inhibitor 1k is used as a candidate for the development of therapeutic agents. Its structure and properties make it a promising compound for further research and development, with potential applications in various medical fields, including antifungal treatments and the study of cytochrome P450 enzymes in drug metabolism and toxicology.
Check Digit Verification of cas no
The CAS Registry Mumber 1155361-09-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,5,3,6 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1155361-09:
(9*1)+(8*1)+(7*5)+(6*5)+(5*3)+(4*6)+(3*1)+(2*0)+(1*9)=133
133 % 10 = 3
So 1155361-09-3 is a valid CAS Registry Number.
1155361-09-3Relevant articles and documents
Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase
Chai, Xiaoyun,Zhang, Jun,Hu, Honggang,Yu, Shichong,Sun, Qingyan,Dan, Zhigang,Jiang, Yuanying,Wu, Qiuye
experimental part, p. 1913 - 1920 (2009/09/30)
Based on the results of computational docking to the active site of the cytochrome P450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. The MIC80 values indicate that compounds 1a-n exhibited higher activity against nearly all fungi tested except Aspergillus fumigatus than fluconazole, while compounds 2a-f, 3a-f showed no activity or only moderate activity against all fungi tested. Noticeably, the MIC value of compounds 1a, 1b and 1g is 64 times lower than that of fluconazole against Microsporum gypseum in vitro. And compounds 1a, 1b and 2b showed 128 times higher activity (with the MIC80 value of 0.0039 μg/mL) than that of fluconazole against Candida albicans and also showed higher activity than that of the other positive controls. Computational docking experiments indicated that the inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft. In addition, the activity of the compounds would be enhanced when the side chains were shorter.