1155811-37-2

Basic information

• Product Name: tert-butyl 2-(2-aminoethoxy)acetate
• Synonyms: tert-butyl 2-(2-aminoethoxy)acetate
• CAS NO: 1155811-37-2
• Molecular Weight: 175.228
• Mol File: 1155811-37-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 247.0±15.0 °C(Predicted)
• Density: 1.006±0.06 g/cm3(Predicted)
• CAS DataBase Reference: tert-butyl 2-(2-aminoethoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(2-aminoethoxy)acetate(1155811-37-2)
• EPA Substance Registry System: tert-butyl 2-(2-aminoethoxy)acetate(1155811-37-2)

Safety Data

• Hazardous Substances Data: 1155811-37-2(Hazardous Substances Data)

Upstream product

• 35059-50-8 t-butyl diazoacetate 
• 98900-24-4 tert-butyl 2-[2-(1,3-dioxoisoindolin-2-yl)ethoxy]acetate 
• 1820717-35-8 2-azidoethoxyacetic acid tert-butyl ester 
• 1643957-24-7 tert-butyl 2-(2-[[(4-methylbenzene)sulfonyl]oxy]ethoxy)acetate 
• 287174-32-7 (2-hydroxyethoxy)acetic acid tert-butyl ester 
• 1309451-06-6 2-(2-(benzyloxy)ethoxy)acetic acid tert-butyl ester 
• 1350753-84-2 2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester 
• 5292-43-3 bromoacetic acid tert-butyl ester 

Downstream Products

• 109-11-5 morpholine-3-one 

Relevant articles and documents

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation

A series of (E)-3-(4-((2,4-bis(trifluoromethyl)benzyl)oxy)-3-methoxyphenyl)-2-cyanoacrylamide derivatives were designed and synthesized as new estrogen-related receptor α (ERRα) degraders based on the proteolysis targeting chimera (PROTAC) concept. One of the representative compounds 6c is capable of specifically degrading ERRα protein by >80% at a relatively low concentration of 30 nM, becoming one of the most potent and selective ERRα degraders to date. Compound 6c could be utilized as a new powerful research tool for further biological investigation of ERRα.

Method for preparing 3-ketomorpholine

The invention relates to a method for preparing 3-ketomorpholine. The method comprises the following steps: protecting the amino group of ethanolamine firstly, then carrying out a reaction of amino group protected ethanolamine with alkyl haloacetate, performing deprotection on the prepared product, and performing ring closure so as to obtain 3-ketomorpholine. The method has the advantages of simple practical operation, low equipment requirements, high yield and low three waste, and is suitable for industrial large-scale production.