115583-65-8

Basic information

• Product Name: 4-Chloro-benzoic acid (3S,5S)-3-(4-chloro-phenyl)-3-imidazol-1-ylmethyl-2-methyl-isoxazolidin-5-ylmethyl ester
• CAS NO: 115583-65-8
• Molecular Weight: 446.333
• Mol File: 115583-65-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Chloro-benzoic acid (3S,5S)-3-(4-chloro-phenyl)-3-imidazol-1-ylmethyl-2-methyl-isoxazolidin-5-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-benzoic acid (3S,5S)-3-(4-chloro-phenyl)-3-imidazol-1-ylmethyl-2-methyl-isoxazolidin-5-ylmethyl ester(115583-65-8)
• EPA Substance Registry System: 4-Chloro-benzoic acid (3S,5S)-3-(4-chloro-phenyl)-3-imidazol-1-ylmethyl-2-methyl-isoxazolidin-5-ylmethyl ester(115583-65-8)

Safety Data

• Hazardous Substances Data: 115583-65-8(Hazardous Substances Data)

Upstream product

• 119393-45-2 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide 
• 115583-63-6 [3-(4-Chloro-phenyl)-3-imidazol-1-ylmethyl-2-methyl-isoxazolidin-5-yl]-methanol 
• 790-41-0 4-chlorobenzoic anhydride 

Relevant articles and documents

Studies on antifungal agents. In vitro activity of novel cis-5-alkoxy (or acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives

The synthesis and in vitro antifungal activity of a novel series of cis-5d-alkoxy (or acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives (6a-n) are described. The 5-[(4-chlorobenzyloxy)methyl] analogue 6h and the two 5-acyloxymethyl derivatives 6k,l demonstrated the best overall potency. Against Candida stellatoidea, the minimum inhibitory concentrations (MIC's) for 6h,k,l ranged between 0.7 and 2.0 μg/ml. The corresponding value for the standard drug ketoconazole was 7-20 μg/ml.