1155872-96-0Relevant articles and documents
Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin
Sunami, Satoshi,Nishimura, Teruyuki,Nishimura, Ikuko,Ito, Satoru,Arakawa, Hiroharu,Ohkubo, Mitsuru
supporting information; experimental part, p. 3225 - 3237 (2010/03/25)
The replacement of 1,3-dihydroxy-2-propylamino moiety at the N6-position of edotecarin (1) by arylmethylamino groups yielded a number of more potent topoisomerase I inhibitors with better cytotoxic (CTX) activities in vitro than edotecarin. Among them, th