115595-01-2 Usage
Chemical class
Azabicycloalkane derivative
Bicyclic structure
Consists of two inter-connected rings
Carboxylic acid functional group
Contains a -COOH group
Application in medicinal chemistry
Used in the development of therapeutic agents and pharmaceuticals
Research and development
Utilized for studying structure-activity relationships of compounds
Synthesis potential
Can be used in the synthesis of other compounds and organic materials
Unique structure
Offers various applications in the chemical and pharmaceutical industries
CAS Registry Number
9CI (Chemical Abstracts Service Registry Number)
Stereochemistry
exo(refers to the spatial arrangement of the carboxylic acid group in relation to the bicyclic ring system)
Check Digit Verification of cas no
The CAS Registry Mumber 115595-01-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,5,9 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 115595-01:
(8*1)+(7*1)+(6*5)+(5*5)+(4*9)+(3*5)+(2*0)+(1*1)=122
122 % 10 = 2
So 115595-01-2 is a valid CAS Registry Number.
115595-01-2Relevant articles and documents
Comparison of Azabicyclic Esters and Oxadiazoles as Ligands for the Muscarinic Receptor
Orlek, Barry S.,Blaney, Frank E.,Brown, Frank,Clark, Michael S. G.,Hadley, Michael S.,et al.
, p. 2726 - 2735 (2007/10/02)
The link between the cognitive deficit associated with Alzheimer type dementia and the loss of cholinergic function in the disease provides a basis for examining muscarinic agonists as potential therapeutic agents.This paper describes the design and synthesis of novel azabicyclic methyl esters as ligands for the muscarinic receptor.Replacement of the methyl ester by a 3-methyl-1,2,4-oxadiazole ring produces potent metabolically more stable muscarinic agonists capable of penetrating the central nervous system.These compounds generally show improved affinity relativeto the corresponding methyl esters. 3-Methyl-1,2,4-oxadiazole 7b has an affinity 4 times that of acetylcholine.Receptor affinity is discussed in relation to the size and geometry of the azabicyclic ring and the electronic properties of the heteroaromatic ring.