115749-98-9

Basic information

• Product Name: 5-((2-(diethylamino)ethyl)amino)-7-methoxy-5,11-dihydro(1)benzoxepino(3,4-b)pyridine
• Synonyms: 5-((2-(diethylamino)ethyl)amino)-7-methoxy-5,11-dihydro(1)benzoxepino(3,4-b)pyridine
• CAS NO: 115749-98-9
• Molecular Formula: C20H27 N3 O2
• Molecular Weight: 341.45
• Mol File: 115749-98-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 461°Cat760mmHg
• Flash Point: 232.6°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 1.12E-08mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 5-((2-(diethylamino)ethyl)amino)-7-methoxy-5,11-dihydro(1)benzoxepino(3,4-b)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((2-(diethylamino)ethyl)amino)-7-methoxy-5,11-dihydro(1)benzoxepino(3,4-b)pyridine(115749-98-9)
• EPA Substance Registry System: 5-((2-(diethylamino)ethyl)amino)-7-methoxy-5,11-dihydro(1)benzoxepino(3,4-b)pyridine(115749-98-9)

Safety Data

• Hazardous Substances Data: 115749-98-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H27N3O2/c1-4-23(5-2)12-11-22-20-16-7-6-10-21-18(16)14-25-19-9-8-15(24-3)13-17(19)20/h6-10,13,20,22H,4-5,11-12,14H2,1-3H3

Upstream product

• 100-36-7 N,N-diethylethylenediamine 
• 129526-20-1 N,N-Diethyl-N'-[7-methoxy-11H-10-oxa-1-aza-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-ethane-1,2-diamine 
• 5657-51-2 7H-furo[3,4-b]pyridin-5-one 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 115750-44-2 7-methoxy-5,11-dihydro<1>benzoxepino<3,4-b>pyridin-5-one 
• 130220-57-4 2-(4-methoxyphenoxymethyl)-3-pyridinecarboxylic acid 
• 81113-14-6 2-hydroxymethyl-3-pyridinecarboxylic acid 
• 115750-35-1 7-methoxy-5,11-dihydro<1>benzoxepino<3,4-b>pyridin-5-ol 

Relevant articles and documents

A facile synthesis of substituted 5,11-dihydro[1]benzoxepino[3,4-b]pyridines

5-Amino-5,11-dihydro[1]benzoxepino[3,4-b]pyridines (1) show anti-ulcer and antiarrhythmic activity. An efficient method for the preparation of a key intermediate, furo[3,4-b]pyridin-5(7H)-one (4), and the facile synthesis of 1 were described. The reduction of quinolinic anhydride (5) with sodium borohydride in the presence of acetic acid regioselectively gave the lactone 4. Lactone 4 was then reacted with substituted phenols under basic conditions and the resultant products, 2-(phenoxymethyl)-3-pyridinecarboxylic acids (3), underwent Friedel-Crafts cyclizations to produce the 5,11-dihydro[1]benzoxepino[3,4-b]pyridin-5-ones (2). Compounds 2 were then converted to imines with amines and successively reduced with zinc in acetic acid to the desired compounds 1.