115758-38-8

Basic information

• Product Name: 2-{4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester
• Synonyms: 2-{4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester
• CAS NO: 115758-38-8
• Molecular Weight: 480.524
• Mol File: 115758-38-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester(115758-38-8)
• EPA Substance Registry System: 2-{4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester(115758-38-8)

Safety Data

• Hazardous Substances Data: 115758-38-8(Hazardous Substances Data)

Upstream product

• 110202-58-9 4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoic acid methyl ester 
• 110202-57-8 methyl 4-<2-(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoate 
• 101810-74-6 2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carboxaldehyde 
• 1253-46-9 4-methoxycarbonylbenzyltriphenylphosphonium bromide 
• 23150-65-4 dimethyl glutamate hydrochloride 
• 110202-59-0 4-<2-(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)ethyl>benzoic acid 

Downstream Products

• 115758-41-3 5-methyl-5,10-dideazafolic acid 
• 110202-60-3 5-methyl-5,10-dideazaaminopterin 

Relevant articles and documents

Synthesis and Antifolate Activity of 5-Methyl-5,10-dideaza Analogues of Aminopterin and Folic Acid and an Alternative Synthesis of 5,10-Dideazatetrahydrofolic Acid, a Potent Inhibitor of Glycinamide Ribonucleotide Formyltransferase

The title compounds were prepared in extensions of a general synthetic approach used earlier to prepare 5-alkyl-5-deaza analogues of classical antifolates.Wittig condensation of 2,4-diaminopyridopyrimidine-6-carboxaldehyde (2a) and its 5-methyl ana