1158443-10-7Relevant articles and documents
Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide
Sunazuka, Toshiaki,Sugawara, Akihiro,Iguchi, Kanami,Hirose, Tomoyasu,Nagai, Kenichiro,Noguchi, Yoshihiko,Saito, Yoshifumi,Yamamoto, Tsuyoshi,Ui, Hideaki,Gouda, Hiroaki,Shiomi, Kazuro,Watanabe, Takeshi,Omura, Satoshi
, p. 2751 - 2758 (2009)
An effective solid phase synthesis of Argifin, providing subsequent access to effective synthesis of analogues, was developed in 13% overall yield, as well as elucidating structure-activity relationships. The novel acyclic peptide 18b, prepared from a synthetic intermediate of Argifin, was found to be 70 times more potent as an inhibitor of Serratia marcescens chitinases B than Argifin itself.