1158953-09-3

Basic information

• Product Name: 7-methoxy-2-(2'-methoxyphenyl)-3-[(4''-carboxy-3''-methoxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one methyl ester
• Synonyms: 7-methoxy-2-(2'-methoxyphenyl)-3-[(4''-carboxy-3''-methoxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one methyl ester
• CAS NO: 1158953-09-3
• Molecular Weight: 536.581
• Mol File: 1158953-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-methoxy-2-(2'-methoxyphenyl)-3-[(4''-carboxy-3''-methoxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxy-2-(2'-methoxyphenyl)-3-[(4''-carboxy-3''-methoxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one methyl ester(1158953-09-3)
• EPA Substance Registry System: 7-methoxy-2-(2'-methoxyphenyl)-3-[(4''-carboxy-3''-methoxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one methyl ester(1158953-09-3)

Safety Data

• Hazardous Substances Data: 1158953-09-3(Hazardous Substances Data)

Upstream product

• 603122-41-4 (3-methoxy-4-(methoxycarbonyl)phenyl)boronic acid 
• 1158953-04-8 2-(4-methoxyphenyl)-3-(4-bromobenzyl)-7-methoxy-4H-1-benzopyran-4-one 

Downstream Products

• 1158952-77-2 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-carboxy-3''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 

Relevant articles and documents

Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors

Protein tyrosine phosphatases (PTP) are crucial elements in eukaryotic signal transduction. Several reports suggested that the LMW-PTP family has oncogenic relevance. Moreover, LMW-PTP has been recognized as a negative regulator of insulin-mediated mitotic and metabolic signaling. Thus, inhibition of the LMW-PTP can be considered an attractive approach for the design of new therapeutic agents for the treatment of type II diabetes and for new antitumoral drugs. To date very few (and weak) inhibitors of LMW-PTP have been identified. On the basis of the reported weak activity of some flavonoids on phosphatases, we discovered a lead that originated a new class of highly active LMW-PTP inhibitors; these compounds inhibit also PTP-1B and are active in cellular assays. Docking experiments and SAR highlighted the possible binding mode of these compounds to the enzyme, putting the background for the future optimization of their inhibitory activity and selectivity towards the closely related enzyme PTP-1B.