115933-00-1

Basic information

• Product Name: 5-[4,4-Bis-(4-methoxy-phenyl)-4H-pyridin-1-yl]-pentanoic acid methyl ester
• CAS NO: 115933-00-1
• Molecular Weight: 407.51
• Mol File: 115933-00-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-[4,4-Bis-(4-methoxy-phenyl)-4H-pyridin-1-yl]-pentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4,4-Bis-(4-methoxy-phenyl)-4H-pyridin-1-yl]-pentanoic acid methyl ester(115933-00-1)
• EPA Substance Registry System: 5-[4,4-Bis-(4-methoxy-phenyl)-4H-pyridin-1-yl]-pentanoic acid methyl ester(115933-00-1)

Safety Data

• Hazardous Substances Data: 115933-00-1(Hazardous Substances Data)

Upstream product

• 115933-12-5 3,3-Bis-(4-methoxy-phenyl)-pentanedial 
• 13031-60-2 methyl γ-aminobutyrate hydrochloride 

Relevant articles and documents

Antihypertensive dihydropyridines with 1,4,4-trisubstitution

Dihydropyridines with 1,4,4-trisubstitution were synthesized and tested for antihypertensive activity in a spontaneously hypertensive rat model. This substitution pattern on the dihydropyridine nucleus differs markedly from that found most active in the structure-activity relationship established for nifedipine-like compounds. However, some were found to significantly lower blood pressure at testing doses (30 mg/kg, ip and 100 mg/kg, po) for up to 24 h. Methyl 1,4-dihydro-4,4-dimethyl-1-pyridinepropanoate (2-1), for example, lowered blood pressure 71 mmHg at 30 mg/kg, ip and the effect endured for greater than 24 h. Unlike prototypical dihydropyridines such as nifedipine, these compounds did not seem to have any effect on calcium channels.