1159505-61-9

Basic information

• Product Name: C₈H₇F₄NO₂S
• Synonyms: C₈H₇F₄NO₂S
• CAS NO: 1159505-61-9
• Molecular Weight: 257.209
• Mol File: 1159505-61-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₈H₇F₄NO₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₇F₄NO₂S(1159505-61-9)
• EPA Substance Registry System: C₈H₇F₄NO₂S(1159505-61-9)

Safety Data

• Hazardous Substances Data: 1159505-61-9(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 36457-58-6 N-benzyl-1,1,1-trifluoromethanesulfonamide 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 89-99-6 2-fluorobenzylamine 

Downstream Products

• 326-62-5 2-fluorophenyl acetonitrile 
• 1082208-85-2 C₈H₆F₅NO₂S 
• 62284-30-4 2-fluorobenzyl azide 
• 1159505-79-9 C₁₈H₂₅FO₄ 
• 1159505-77-7 C₉H₉F₄NO₂S 
• 399-30-4 1-(2-fluorophenyl)-N-methylmethanamine 
• 1429477-05-3 1,1,1-trifluoro-N-(2-fluoro-6-(4-methoxybenzoyl)benzyl)methanesulfonamide 

Relevant articles and documents

Ligand-promoted ortho-C-H amination with Pd catalysts

2,4,6-Trimethoxypyridine is identified as an efficient ligand for promoting a Pd-catalyzed ortho-C-H amination of both benzamides and triflyl-protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable PdII-catalyzed Csp2-H activation reactions directed by weakly coordinating functional groups.

Versatile Pd(OTf)2·2H2O-catalyzed ortho-fluorination using NMP as a promoter

(Chemical Equation Presented) Pd(OTf)2·2H 2O-catalyzed ortho-fluorination of triflamide-protected benzylamines is reported. The use of N-fluoro-2,4,6-trimethylpyridinium triflate as the F+ source and NMP as a promoter is crucial for this reaction. The conversion of triflamide into a wide range of synthetically useful functional groups makes this fluorination protocol broadly applicable in medicinal chemistry and synthesis.