1159733-63-7

Basic information

• Product Name: 2-cyano-5-dimethylaminopyridine
• CAS NO: 1159733-63-7
• Molecular Weight: 147.18
• Mol File: 1159733-63-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-cyano-5-dimethylaminopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-5-dimethylaminopyridine(1159733-63-7)
• EPA Substance Registry System: 2-cyano-5-dimethylaminopyridine(1159733-63-7)

Safety Data

• Hazardous Substances Data: 1159733-63-7(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 55338-73-3 5-amino-2-cyanopyridine 
• 327056-62-2 5-fluoropicolinonitrile 
• 124-40-3 dimethyl amine 
• 74-88-4 methyl iodide 

Relevant articles and documents

Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease

To elucidate the involvement of individual and inter-related pathological factors [i.e., amyloid-β (Aβ), metals, and oxidative stress] in the pathogenesis of Alzheimer's disease (AD), chemical tools have been developed. Characteristics required for such tool construction, however, have not been clearly identified; thus, the optimization of available tools or new design has been limited. Here, key structural properties and mechanisms that can determine tools’ regulatory reactivities with multiple pathogenic features found in AD are reported. A series of small molecules was built up through rational structural selection and variations onto the framework of a tool useful for in vitro and in vivo metal–Aβ investigation. Variations include: (i) location and number of an Aβ interacting moiety; (ii) metal binding site; and (iii) denticity and structural flexibility. Detailed biochemical, biophysical, and computational studies were able to provide a foundation of how to originate molecular formulas to devise chemical tools capable of controlling the reactivities of various pathological components through distinct mechanisms. Overall, this multidisciplinary investigation illustrates a structure–mechanism-based strategy of tool invention for such a complicated brain disease.

HYDRAZNE DERIVATIVES FOR THE TREATMENT OF CANCER

The invention provides compounds of formula (I): and salts thereof, wherein ring A, R2, HET, X, n, and R3 have any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts.

DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES

Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.