115976-91-5

Basic information

• Product Name: PHILANTHOTOXIN 433 TRIFLUOROACETATE
• Synonyms: (s)-n-[4-[[3-[(3-aminopropyl)amino]propyl]amino]butyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide tris-triethylammonium salt;philanthotoxin 433 tris(trifluoroacetate) salt;(S)-N-[4-[[3-[(3-Aminopropyl)amino]propyl]amino]butyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide;N-[4-[3-(3-Aminopropylamino)propylamino]butyl]-Nα-butyryl-L-tyrosinamide;Philanthotoxin;Philanthotoxin 433;δ-Philanthotoxin;PHILANTHOTOXIN 433 TRIFLUOROACETATE
• CAS NO: 115976-91-5
• Molecular Formula: C₂₃H₄₁N₅O₃
• Molecular Weight: 435.609
• Mol File: 115976-91-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 716.9°C at 760 mmHg
• Flash Point: 387.4°C
• Appearance: white/solid
• Density: 1.084g/cm³
• Vapor Pressure: 3.07E-21mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: −20°C
• Solubility: H2O: ≥10 mg/mL
• CAS DataBase Reference: PHILANTHOTOXIN 433 TRIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: PHILANTHOTOXIN 433 TRIFLUOROACETATE(115976-91-5)
• EPA Substance Registry System: PHILANTHOTOXIN 433 TRIFLUOROACETATE(115976-91-5)

Safety Data

• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 115976-91-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C23H41N5O3/c1-2-7-22(30)28-21(18-19-8-10-20(29)11-9-19)23(31)27-17-4-3-13-25-15-6-16-26-14-5-12-24/h8-11,21,25-26,29H,2-7,12-18,24H2,1H3,(H,27,31)(H,28,30)/t21-/m0/s1

Upstream product

• 130203-42-8 O-Benzyl-PhTX-4'-N-Cbz-433 
• 56-18-8 bis(3-aminopropyl)amine 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 209115-32-2 9H-fluoren-9-ylmethyl N-(4-hydroxybutyl)carbamate 
• 107-92-6 butyric acid 
• 167568-21-0 bis-(3-amino-propyl)-carbamic acid tert-butyl ester 
• 34805-17-9 methyl 2S-amino-3-(4-benzyloxyphenyl)propionate hydrochloride 
• 172992-35-7 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 
• 172992-34-6 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester 
• 172992-36-8 N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-hydroxy-butylcarbamoyl)-ethyl]-butyramide 
• 172992-37-9 N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide 
• 68076-41-5 tert-butyl 2-cyanoethyl-{4-[(tert-butoxycarbonyl)amino]butyl}carbamate 
• 68076-39-1 N₁,N₅-di-boc-spermidine 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 

Relevant articles and documents

Solid-phase synthesis of polyamines using a Dde-linker: Philanthotoxin- 4.3.3 via an on-resin Mitsunobu reaction

A Dde linker/solid-phase procedure for the stepwise construction of polyamines is illustrated with the synthesis of philanthotoxin-4.3.3. Resin- bound 4-aza-1,7-heptanediamine was N4-protected and N7-activated in a single operation with 2-nitrobenzenesulphonyl chloride. Alkylation with N- Fmoc-4-aminobutanol under Mitsunobu conditions completed the polyamine backbone. Deprotection of the sulphonamide groups was readily achieved with thiolates in DMF at room temperature. (C) 2000 Elsevier Science Ltd.

Synthesis of glutamate receptor antagonist philanthotoxin-433 (PhTX-433) and its analogs

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