1159977-03-3

Basic information

• Product Name: 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B)
• Synonyms: 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B);Anagrelide IMpurity B;2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid;(2-Amino-5,6-Dichloroquinazolin-3(4H)-Yl)Acetic Acid Hydrochloride;USP Anagrelide Related Impurity B;USP Anagrelide Related Impurities
• CAS NO: 1159977-03-3
• Molecular Formula: C10H9Cl2N3O2
• Molecular Weight: 274.10336
• Product Categories: Amines;Bases & Related Reagents;Impurities;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Amines, Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1159977-03-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 538.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.69±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• PKA: 7.58±0.70(Predicted)
• CAS DataBase Reference: 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B)(1159977-03-3)
• EPA Substance Registry System: 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B)(1159977-03-3)

Safety Data

• Hazardous Substances Data: 1159977-03-3(Hazardous Substances Data)

Usage

Description

2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B) is a chemical compound derived from quinazoline, a heterocyclic organic compound with a tricyclic structure. It is characterized by the presence of two chlorine atoms at positions 5 and 6, and an amino group at position 2. This impurity is often found in the synthesis of Anagrelide, a drug used for the treatment of certain blood disorders.

Uses

Used in Pharmaceutical Industry:
2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B) is used as an intermediate compound in the synthesis of Anagrelide, a medication prescribed for the treatment of thrombocythemia, a blood disorder characterized by an abnormally high count of platelets in the blood. It is also used in the development of other pharmacologically active compounds due to its wide spectrum of biological activities.
Used in Research and Development:
In the field of medicinal chemistry, 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B) serves as a valuable research tool for understanding the structure-activity relationships of quinazoline derivatives. This knowledge can be applied to design and develop new drugs with improved efficacy and safety profiles for various therapeutic applications, including anticonvulsant, antibacterial, and antidiabetic agents.
Used in Quality Control and Regulatory Compliance:
The presence of Anagrelide Impurity B in the final drug product must be monitored and controlled to ensure the safety and efficacy of the medication. It is used in quality control processes to test and validate the purity of Anagrelide, helping pharmaceutical companies meet regulatory requirements and maintain product quality standards.