116003-04-4

Basic information

• Product Name: N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite
• CAS NO: 116003-04-4
• Molecular Weight: 833.921
• Mol File: 116003-04-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite(116003-04-4)
• EPA Substance Registry System: N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite(116003-04-4)

Safety Data

• Hazardous Substances Data: 116003-04-4(Hazardous Substances Data)

Upstream product

• 951-77-9 2'-Deoxycytidine 
• 4836-13-9 N₄-benzoyl-2'-deoxycytidine 
• 98-88-4 benzoyl chloride 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 67219-55-0 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 108-18-9 diisopropylamine 
• 133728-83-3 C₄₉H₆₂N₅O₇P 
• 109-78-4 3-Hydroxypropionitrile 
• 140613-57-6 5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite] 
• 93-97-0 benzoic acid anhydride 
• 174647-46-2 2-cyanoethoxy(N,N-diisopropylamino)3-nitro-1,2,4-triazolylphosphine 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 

Downstream Products

• 1305318-68-6 C₆₀H₇₀N₉O₁₃PSi 
• 1305318-78-8 C₃₉H₅₂N₉O₁₁PSi 
• 1305319-03-2 C₇₇H₉₁N₁₅O₂₀P₂Si 
• 1021543-79-2 C₆₀H₇₀N₉O₁₄PSi 
• 1305318-75-5 C₆₂H₆₈N₇O₁₄PSi 

Relevant articles and documents

ON-DEMAND PHOSPHORAMIDITE SYNTHESIS

The invention relates to a method of synthesis of phosphoramidites by immobilization of a phosphitylation agent on a resin activated to create a charged resin, then putting in contact with the charged resin with a suitable substrate. Phosphoramidites are synthesized in a few minutes from the application of the starting materials. Thus, the process makes it possible to create specific phosphoramidites on demand when they are needed in other applications. The substrates to be applied are mainly nucleosides, thus making it possible to create nucleoside phosphoramidites for the subsequent synthesis of oligonucleotides.

A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotide phosphoramidites

Herein we report a convenient approach for the preparation of fully protected trinucleotide synthons to be used for the synthesis of gene libraries. The trinucleotide synthons bear β-cyanoethyl groups at the phosphate residues, and thus can be used in standard oligonucleotide synthesis without additional steps for deprotection and work-up.

Convenient synthesis of N-unprotected deoxynucleoside 3′- phosphoramidite building blocks by selective deacylation of N-acylated species and their facile conversion to other N-functionalized derivatives

(Chemical Equation Presented) A new route to N-unprotected deoxynucleoside 3′-phosphoramidite building blocks by use of highly selective N-deacylation of commercially available N-acylated deoxynucleoside 3′-phosphoramidites is described. These compounds could be readily converted to other types of N-protected species by facile N-acylations with acylating reagents.