1160096-68-3

Basic information

• Product Name: 2,6-bis(4-(trifluoromethyl)phenyl)pyridine
• Synonyms: 2,6-bis(4-(trifluoromethyl)phenyl)pyridine
• CAS NO: 1160096-68-3
• Molecular Weight: 367.293
• Mol File: 1160096-68-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2,6-bis(4-(trifluoromethyl)phenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis(4-(trifluoromethyl)phenyl)pyridine(1160096-68-3)
• EPA Substance Registry System: 2,6-bis(4-(trifluoromethyl)phenyl)pyridine(1160096-68-3)

Safety Data

• Hazardous Substances Data: 1160096-68-3(Hazardous Substances Data)

Upstream product

• 53710-17-1 2,6-diiodo-pyridine 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 626-05-1 2,6-Dibromopyridine 
• 98-80-6 phenylboronic acid 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 56-40-6 glycine 
• 110-86-1 pyridine 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 98-98-6 2-Picolinic acid 
• 718628-25-2 (4-(trifluoromethyl)phenyl)zinc(II) iodide 

Relevant articles and documents

Green and sustainable palladium nanomagnetic catalyst stabilized by glucosamine-functionalized Fe3O4@SiO2 nanoparticles for Suzuki and Heck reactions

A novel magnetic and heterogeneous palladium-based catalyst stabilized by glucosamine-functionalized magnetic Fe3O4@SiO2 nanoparticle was synthesized. The strategy relies on the covalently bonding of glucosamine to cyanuric chloride-functionalized magnetic nanoparticles followed by complexation with palladium. The structure of magnetic nanocatalyst was fully determined by FT-IR, XRD, DLS, FE-SEM, TEM, ICP, UV-Vis, TGA, VSM, and EDX. The obtained results confirmed that the palladium nanoparticles stabilized by glucosamine immobilized onto the magnetic support exhibited high activity in cross-coupling reactions of Suzuki-Miyaura and Mizoroki-Heck. Various aryl halides were coupled with arylboronic acid (Suzuki cross-coupling reaction) and olefins (Heck reactions) under the green conditions to provide corresponding products in high to excellent yields. Interestingly, the catalyst can be easily isolated from the reaction media by magnetic decantation and can subsequently be applied for consecutive reaction cycles (at least seven times) with no notable reduction in the catalytic activity.

Sustainable and recyclable magnetic nanocatalyst of 1,10-phenanthroline Pd(0) complex in green synthesis of biaryls and tetrazoles using arylboronic acids as versatile substrates

A magnetic nanocatalyst was purveyed as a heterogeneous recoverable palladium-based catalyst anchored on green, sustainable and phosphine free support. Resulted Fe3O4@SiO2-Phen-Pd(0) nanocatalyst bearing powerful phenanthroline ligand was thoroughly characterized by physicochemical approaches like UV–vis, FT-IR, EDX, XRD, TGA, ICP, VSM, DLS, FESEM, and TEM analyses. After finding trustable data, the obtained magnetic catalyst was considered to be applied in the Suzuki-Miyaura type C-C couplings and getting corresponding tetrazoles using arylboronic acid derivatives as alternate precursors of aromatic halides and stupendous data were observed.

Direct C-H Functionalization of Pyridine via a Transient Activator Strategy: Synthesis of 2,6-Diarylpyridines

A Pd-catalyzed highly selective direct diarylation of pyridines has been developed using a transient activator strategy. Both (MeO)2SO2 and Cu2O are required for this transformation. The in situ generated N-methylpyridinium salt can be arylated at both 2- and 6-positions under the cooperative Pd/Cu catalysis. A subsequent N-demethylation then gives the 2,6-diarylpyridines. This protocol provides a novel synthetic route for the symmetric 2,6-diarylpyridines.