116021-13-7

Basic information

• Product Name: Propanoic acid, 2-methyl-3-(triphenylmethoxy)-, methyl ester, (2S)-
• CAS NO: 116021-13-7
• Molecular Formula: C24H24O3
• Molecular Weight: 360.453
• Mol File: 116021-13-7.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-methyl-3-(triphenylmethoxy)-, methyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-methyl-3-(triphenylmethoxy)-, methyl ester, (2S)-(116021-13-7)
• EPA Substance Registry System: Propanoic acid, 2-methyl-3-(triphenylmethoxy)-, methyl ester, (2S)-(116021-13-7)

Safety Data

• Hazardous Substances Data: 116021-13-7(Hazardous Substances Data)

Upstream product

• 80657-57-4 3-hydroxy-(2S)-methylpropionate 
• 5333-62-0 benzyl trityl ether 
• 76-84-6 triphenylmethyl alcohol 
• 76-83-5 trityl chloride 

Downstream Products

• 1366246-12-9 1-methoxy-4-({[(5R)-5-methyl-6-(triphenylmethoxy)hexyl]oxy}methyl)benzene 
• 1093386-28-7 tert-butyl {[(2R)-2-methyl-3-(trityloxy)propyl]oxy}acetate 
• 1073630-34-8 (-)-{[(2R)-2-methyl-3-(trityloxy)propyl]oxy}acetic acid ethyl ester 
• 123595-49-3 (2S)-2-methyl-3-(triphenylmethoxy)-propyl 4-methylbenzenesulfonate 
• 123595-51-7 (R)-4-Methyl-5-trityloxy-pentan-1-ol 
• 123595-50-6 C₂₆H₂₈O 
• 116051-93-5 (3R,4S)-1-(p-anisyl)-3-acetyl-4-<(R)-1-(triphenylmethoxymethyl)ethyl>-2-azetidinone 
• 116001-87-7 (3S,4R)-1-(p-anisyl)-3-acetyl-4-<(R)-1-(triphenylmethoxymethyl)ethyl>-2-azetidinone 
• 118673-41-9 (4-Methoxy-phenyl)-[(R)-2-methyl-3-trityloxy-prop-(E)-ylidene]-amine 
• 111956-40-2 (3R,4S)-1-(di-p-anisylmethyl)-3-acetyl-4-<(R)-1-(triphenylmethoxymethyl)ethyl>-2-azetidinone 
• 111865-80-6 (3S,4R)-1-(di-p-anisylmethyl)-3-acetyl-4-<(R)-1-(triphenylmethoxymethyl)ethyl>-2-azetidinone 
• 111865-75-9 [Bis-(4-methoxy-phenyl)-methyl]-[(R)-2-methyl-3-trityloxy-prop-(E)-ylidene]-amine 
• 152999-17-2 (E)-(2S,3S)-2,4-Dimethyl-1-trityloxy-hex-4-en-3-ol 
• 124928-83-2 C₃₀H₃₀O₂ 

Relevant articles and documents

Formal synthesis of borrelidin: A highly enantio- and diastereoselective access to the Morken's C2-C12 intermediate

In contrast to methyl and isobutyl phenyl sulfone, condensing under basic conditions higher alkyl sulfones and trans-2,3-epoxy-butanol 13c (or its O-benzyl and O-silyl derivatives) proved unfeasible, a difficulty that was overcome by using mono ethers of trans-2,3-epoxy-butane-1,4-diol 35c as the electrophilic reagents. Thus, adding excess BuLi to a mixture of the benzyl ether 35b and sulfone ent-12a, a stereodiad sulfone prepared in pure state from the R-Roche ester, via the O-trityloxy-sulfone ent-12c (X-ray), gave, after elimination by column chromatography of the side-formed regioisomer, a diolsulfone that was next converted to sulfone 20 by means of conventional functional-group modifications. Reacting like-wise this sulfone with the parent O-PMB derivative 35a, and then proceeding to the same purification process and function adjustment, delivered the title fragment in virtually pure state.

Gold(I)-catalyzed synthesis of unsymmetrical ethers using alcohols as alkylating reagents

A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis.

SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF

The present application relates to novel substituted furopyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.