1160707-44-7

Basic information

• Product Name: 1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone
• Synonyms: 1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone
• CAS NO: 1160707-44-7
• Molecular Weight: 287.7
• EINECS: -0
• Mol File: 1160707-44-7.mol
• Article Data: 47

Chemical Properties

• CAS DataBase Reference: 1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone(1160707-44-7)
• EPA Substance Registry System: 1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone(1160707-44-7)

Safety Data

• Hazardous Substances Data: 1160707-44-7(Hazardous Substances Data)

Usage

Description

1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone is a chemical compound belonging to the phenyl ethanone class, characterized by its molecular formula C13H14ClNO5. This yellow solid has a molecular weight of 295.71 g/mol and is known for its potential therapeutic properties. It features a nitro group, a chloro group, and a methoxy group, which contribute to its versatility in chemical and medicinal applications.

Uses

Used in Research and Development:
1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone is used as a research compound for exploring its chemical properties and potential applications in various scientific fields. Its unique structure allows researchers to study its interactions with other molecules and its behavior under different conditions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone is used as a starting material or intermediate in the synthesis of various drugs. Its functional groups make it a valuable building block for creating new molecules with specific therapeutic effects.
Used in Chemical Synthesis:
1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone is used as a versatile intermediate in the synthesis of a wide range of chemical products. Its functional groups can be further modified or reacted with other compounds to produce new molecules with desired properties for various applications.
Used in Medicinal Chemistry:
1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)ethanone is used as a key component in the development of new drugs and pharmaceuticals. Its unique structure and functional groups make it a promising candidate for the design of novel therapeutic agents with potential applications in treating various diseases and medical conditions.

Upstream product

• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 58113-30-7 4-(3-chloropropoxy)-3-methoxyacetophenone 
• 3245-49-6 1-[4-(3-bromopropoxy)-3-methoxyphenyl]ethanone 

Downstream Products

• 1219937-96-8 1-[5-methoxy-4-(3-morpholin-4-yl-propoxy)-2-nitro-phenyl]-ethanone 
• 1456775-39-5 C₃₃H₂₉Cl₂FN₆O₆ 
• 1491142-23-4 N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-phenyl-pyrimidine-2-carboxamide 
• 1491142-24-5 N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-methylphenyl)pyrimidine-2-carboxamide 
• 1491142-25-6 N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide 
• 1491142-26-7 N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide 
• 1491142-27-8 N-[3-fluoro-4-[[6-methoxy-7-[3-(1-piperidinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-phenylpyrimidine-2-carboxamide 
• 1491142-28-9 N-[3-fluoro-4-[[6-methoxy-7-[3-(1-piperidinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-methylphenyl)pyrimidine-2-carboxamide 
• 1491142-29-0 N-[3-fluoro-4-[[6-methoxy-7-[3-(1-piperidinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide 
• 1491142-30-3 N-[3-fluoro-4-[[6-methoxy-7-[3-(1-piperidinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide 
• 1491142-31-4 N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-methylphenyl)pyrimidine-2-carboxamide 
• 1491142-32-5 N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide 
• 1491142-33-6 N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide 
• 1491142-34-7 N-[3-fluoro-4-[[6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-phenylpyrimidine-2-carboxamide 

Relevant articles and documents

Design and optimization of novel 4-(2-fluorophenoxy)quinoline derivatives bearing a hydrazone moiety as c-Met kinase inhibitors

A series of 4-(2-fluorophenoxy)quinoline derivatives containing an acylhydrazone moiety were designed, synthesized and evaluated for their in vitro biological activities against c-Met kinase and five cancer cell lines (A549, H460, HT-29, MKN-45, and U87MG). Most compounds showed weak to excellent antiproliferative activity. The most promising analog, 40 (c-Met IC50 Combining double low line 1.86 nM), displayed 1.3-, 6.8-, 1.5-, 3.5-fold increase against HT-29, H460, A549 and U87MG cell lines, respectively, compared with Foretinib. An analysis of structure-activity relationships revealed that an acylhydrazone scaffold with an unsubstituted sp2 hybridized carbon adjacent to the 4-CF3 phenyl ring is favorable for antitumor activity.

New Synthetic Process for Bosutinib

A new and improved synthetic route to bosutinib is described on a hectogram scale. The key step is the intramolecular cyclization of a 3-(2-aminophenyl)-3-oxopropanenitrile with N,N-dimethylformamide dimethyl acetal to form the 3-cyano-4-hydroxyquinoline ring of 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile. A practical synthetic method to 2,4-dichloro-5-methoxyaniline is also established. Bosutinib is obtained in 18.0% yield over nine steps from acetovanillone with 98.9% purity (HPLC).

Novel substituted pyrazolo [1, 5-a] pyrimidine compound and preparation method and application thereof

The invention provides a novel substituted pyrazolo [1, 5-a]pyrimidine compound and a preparation method and application thereof, and particularly relates to a pyrazolo [1, 5-a]pyrimidine-containing quinoline derivative shown as a general formula (I) and pharmaceutically acceptable salts thereof, and substituent groups X, Ar and A have meanings given in the specification. The invention also relates to a compound represented by the general formula (I), wherein the compound has a strong c-Met kinase inhibition effect. The invention also relates to application of the compound and the pharmaceutically acceptable salt thereof in preparation of drugs for treating and/or preventing diseases caused by abnormal high expression of c-Met kinase, especially application in preparation of drugs for treating and/or preventing cancers.

1,3-disubstituted urea and thiourea derivative and application thereof

The invention discloses a 1,3-disubstituted urea and thiourea derivative and application thereof in the field of pharmaceutical chemistry. A structural formula of the derivative is as shown in the specification, and the derivative gives play to an antitumor function through inhibition of tyrosine protein kinase activity, wherein main tyrosine protein kinase inhibited by the derivative includes c-Met, IGF-1R, Src, c-Kit and the like. The derivative can be used for preparation of medicines for preventing or treating hyperplastic diseases, lung cancers, liver cancers, gastric cancers, colon cancers and breast cancers.