1160759-52-3

Basic information

• Product Name: 4-cyano-3-Methylbenzoyl chloride
• Synonyms: 4-cyano-3-Methylbenzoyl chloride
• CAS NO: 1160759-52-3
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.60304
• EINECS: 919-750-3
• Mol File: 1160759-52-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-cyano-3-Methylbenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyano-3-Methylbenzoyl chloride(1160759-52-3)
• EPA Substance Registry System: 4-cyano-3-Methylbenzoyl chloride(1160759-52-3)

Safety Data

• Hazardous Substances Data: 1160759-52-3(Hazardous Substances Data)

Upstream product

• 73831-13-7 4-cyano-3-methylbenzoic acid 
• 67832-11-5 4-bromo-2-methylbenzonitrile 
• 7697-28-1 4-bromo-3-methylbenzoic acid 

Downstream Products

• 479232-57-0 (2S)-N-[[4-[(4,10-dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide 
• 1204706-59-1 4-cyano-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethyl-propyl)-6-methyl-phenyl]-3-methyl-benzamide 
• 335155-20-9 1-(4-Cyano-3-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 847375-16-0 WAY-267464 

Relevant articles and documents

Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors

A previously identified, non-peptidic oxytocin (OT) receptor agonist WAY-267,464 (1) and nine novel derivatives (3, 4a-7a, 4b-7b) were synthesised and evaluated in vitro with the aim of systematically exploring hydrogen bonding interactions and ligand flexibility. All analogues were subjected to competition radioligand binding assays at human oxytocin (OT) and arginine vasopressin 1a (V1a) receptors. Physiological activity was determined using whole cell IP1 accumulation assays. Under these conditions, WAY-267,464 had higher affinity for the V1a receptor compared to the OT receptor (8.5x more selective) with poor functional selectivity (2x selective for OT receptor agonism over V1a receptor antagonism). Methylation of the resorcinol moiety (3) reversed the OT receptor pharmacological profile, removing agonist activity and inducing antagonist activity, without altering V1a receptor pharmacology. All flexible tethered derivatives removed OT receptor affinity and activity resulting in the generation of highly selective V1a receptor ligands.

PESTICIDAL CARBOXAMIDES

The object of the present invention is to provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Disclosed are the carboxamides represented by the following Formula (I) wherein each substituent is as defined in the specif

Subtlety of the Structure-Affinity and Structure-Efficacy Relationships around a Nonpeptide Oxytocin Receptor Agonist

Very few nonpeptide oxytocin agonists have currently been reported, and none of them seem suitable for the in vivo investigation of the oxytocin mediated functions. In an attempt to rationalize the design of better tools, we have systematically studied the structural determinants of the affinity and efficacy of representative ligands of the V1a, V2, and OT receptor subtypes. Despite apparently obvious similarity between the ligand structures on one hand, and between the receptor subtypes on the other hand, the binding affinity and the functional activity profiles of truncated and hybrid ligands highlight the subtlety of ligand-receptor interactions for obtaining nonpeptide OT receptor agonists.