1160861-53-9 Usage
Description
2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos is a dialkylbiaryl phosphine ligand developed by the Buchwald group. It is known for promoting cross-coupling reactions more efficiently and exhibiting improved reactivity compared to other catalytic systems.
Uses
Used in Pharmaceutical Industry:
2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos is used as a ligand in cross-coupling reactions for the synthesis of pharmaceutical compounds. Its improved reactivity and efficiency in promoting these reactions contribute to the development of new and innovative drugs.
Used in Chemical Research:
2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos is used as a ligand in various chemical research applications, particularly in the field of organometallic chemistry. Its enhanced reactivity allows for the synthesis of complex organic molecules and the exploration of new chemical reactions and pathways.
Reaction
Ligand used in the Pd-catalyzed conversion of aryl and vinyl triflates to bromides and chlorides.
Ligand used in the Pd-catalyzed O-arylation of ethyl acetohydroximates.
Ligand used in the Pd-catalyzed conversion of aryl chlorides, triflates, and nonaflates to nitroaromatics.
Ligand used in the Pd-catalyzed cross-coupling of amides and aryl mesylates.
Check Digit Verification of cas no
The CAS Registry Mumber 1160861-53-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,8,6 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1160861-53:
(9*1)+(8*1)+(7*6)+(6*0)+(5*8)+(4*6)+(3*1)+(2*5)+(1*3)=139
139 % 10 = 9
So 1160861-53-9 is a valid CAS Registry Number.
1160861-53-9Relevant articles and documents
Method for synthesizing large-steric-hindrance biphenyl organic phosphine compound
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Paragraph 0006; 0020-0021, (2020/08/09)
The invention discloses a method for synthesizing a large-steric-hindrance biphenyl organic phosphine compound, relates to a synthesis method of 2-dialkylphosphine-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl, and belongs to the field of organic synthesis. In a water-free oxygen-free atmosphere, dialkyl phosphine chloride is used as a raw material to react with magnesium to generate dialkyl phosphine magnesium chloride, and then dialkyl phosphine magnesium chloride reacts with 2-halo-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl under the action of a nickel catalyst to generate 2-dialkylphosphine-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl. Compared with the prior art, the method has the advantages of mild reaction conditions, high yield and simple post-treatment, and is suitable for industrial production.
LIGANDS FOR TRANSITION-METAL-CATALYZED CROSS-COUPLINGS, AND METHODS OF USE THEREOF
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Page/Page column 116, (2009/07/17)
Ligands for transition metals are disclosed herein, which may be used in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The disclosed methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition-metal-catalyzed cross-coupling reactions.