116091-64-6 Usage
Description
5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride is a complex organic compound with a unique chemical structure. It is an impurity and metabolite of the α1-adrenergic blocking agent Tamsulosin, which is used for treating benign prostatic hyperplasia and other conditions. 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride exhibits optical activity, indicating that it has stereoisomers.
Uses
Used in Pharmaceutical Industry:
5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride is used as an impurity and metabolite in the development and analysis of Tamsulosin, an α1-adrenergic blocking agent. Its presence in the pharmaceutical compound helps researchers understand the drug's metabolism and potential side effects, ensuring the safety and efficacy of the medication.
Used in Research and Development:
In the field of medicinal chemistry, 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride serves as a valuable research tool for studying the structure-activity relationship of α1-adrenergic blockers. This knowledge can be applied to design and develop new drugs with improved therapeutic properties and reduced side effects.
Used in Quality Control and Analysis:
5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride is utilized in quality control processes to ensure the purity and potency of Tamsulosin and its formulations. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry can be employed to detect and quantify this impurity, ensuring that the final product meets the required standards for safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 116091-64-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,0,9 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 116091-64:
(8*1)+(7*1)+(6*6)+(5*0)+(4*9)+(3*1)+(2*6)+(1*4)=106
106 % 10 = 6
So 116091-64-6 is a valid CAS Registry Number.
116091-64-6Relevant articles and documents
Preparation method of tamsulosin hydrochloride
-
Paragraph 0041-0043, (2020/07/13)
The invention provides a preparation method of tamsulosin hydrochloride. Specifically, the preparation method comprises a step of reacting 5-acetonyl-2-methoxybenzenesulfonamide with (R)-1-phenylethylamine under the action of a reducing agent to obtain a compound as shown in a formula (IV) or pharmaceutically acceptable salt thereof, and further comprises a step of preparing tamsulosin hydrochloride from the compound as shown in the formula (IV) or pharmaceutically acceptable salt thereof. The preparation method provided by the invention is high in safety and strong in operability, avoids theuse of a heavy metal catalyst, and has an industrial actual use value.
Tamsulosin derivative
-
Page/Page column 11, (2008/06/13)
The optically active compound, R(?)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-hydroxybenzenesulfonamide in good optical purity, a metabolite of the α1-adrenergic blocking agent tamsulosin, and methods for the preparation thereof. Pharmaceutical compositions including the optically active compound and methods of treatment comprising administration of an effective α-adrenergic antagonistic amount of such compositions to mammals.
