116114-18-2Relevant articles and documents
The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating
Baxendale, Ian R.,Ley, Steven V.,Martinelli, Marisa
, p. 5323 - 5349 (2007/10/03)
Herein, we report on the preparation of a library of 5-substituted-2-amino- 1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products.
2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents
Kane,Baron,Dudley,Sorensen,Staeger,Miller
, p. 2772 - 2777 (2007/10/02)
A series of 5-aryl-2,4-dihydro-3H-1,2,4-triazol-3-ones was evaluated for anticonvulsant activity. In general the members of this series were prepared by the alkaline crystalization of 1-aroyl-4-alkylsemicarbazides. The resulting 2-unsubstituted 3H-1,2,4-t
Process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones
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, (2008/06/13)
This invention relates to a novel process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3--thiones, useful as antidepressants, through the thionation of the corresponding 5-aryl-2,4-dialkyl-3H-1,2,4-triazol--3-ones.