116140-28-4Relevant articles and documents
Preparation of polyfunctional pyridines by a palladium(0)-catalyzed cross-coupling of functionalized aryl Grignard reagents
Bonnet, Véronique,Mongin, Florence,Trécourt, Francois,Quéguiner, Guy,Knochel, Paul
, p. 5717 - 5719 (2001)
Difunctionalized pyridines can be prepared by a Pd(0)-catalyzed cross-coupling of functionalized arylmagnesium compounds with chloro- or bromopyridines at temperatures as low as -40°C. An addition-elimination mechanism involving a palladate intermediate is proposed.
Five-membered azole heterocyclic compound and its preparation method, pharmaceutical composition and use thereof
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Paragraph 0644; 0645; 0646, (2017/02/28)
The present invention relates to a five-membered azole heterocycle compound represented by the following general formula (I), a preparation method of the five-membered azole heterocycle compound, a drug composition of the five-membered azole heterocycle compound, and a use of the five-membered azole heterocycle compound in preparation of drugs for prevention or treatment of TGR5-mediated diseases. The formula (I) is represented by the instruction.
Selective Co/Ti cooperatively catalyzed biaryl couplings of aryl halides with aryl metal reagents
Zeng, Jing,Liu, Kun Ming,Duan, Xin Fang
supporting information, p. 5342 - 5345 (2013/11/06)
Various aryl bromides or chlorides, including those bearing a free COOH, OH, CONHR, and SO2NHR group, coupled with aryl magnesium or lithium reagents in the presence of 7.5 mol % CoCl2/15 mol % PBu3 and substoichiometric Ti(OEt)4 (40 mol % to ArM) at room temperature in high yields with high chemo- and regioslectivity. This simple reaction represents the first example of Co/Ti cooperative catalysis which plays a key role in suppressing undesired homocouplings.