1161499-39-3

Basic information

• Product Name: (S)-tert-butyl 2-((S)-1-amino-1-oxo-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ylcarbamoyl)piperidine-1-carboxylate
• Synonyms: (S)-tert-butyl 2-((S)-1-amino-1-oxo-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ylcarbamoyl)piperidine-1-carboxylate
• CAS NO: 1161499-39-3
• Molecular Weight: 501.431
• Mol File: 1161499-39-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 2-((S)-1-amino-1-oxo-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ylcarbamoyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 2-((S)-1-amino-1-oxo-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ylcarbamoyl)piperidine-1-carboxylate(1161499-39-3)
• EPA Substance Registry System: (S)-tert-butyl 2-((S)-1-amino-1-oxo-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ylcarbamoyl)piperidine-1-carboxylate(1161499-39-3)

Safety Data

• Hazardous Substances Data: 1161499-39-3(Hazardous Substances Data)

Upstream product

• 1161498-12-9 (S)-tert-butyl 2-((S)-1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl carbamoyl)piperidine-1-carboxylate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1161499-40-6 tert-butyl (S)-2-((S)-1-amino-3-(4-(6-cyanopyridin-3-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)piperidine-1-carboxylate 
• 1161500-18-0 tert-butyl (S)-2-((S)-1-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)piperidine-1-carboxylate 
• 1258324-56-9 (S)-tert-butyl 2-((S)-1-amino-3-(4'-(ethylsulfonyl)biphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)piperidine-1-carboxylate 
• 1258324-50-3 (S)-tert-butyl 2-((S)-1-amino-3-(4-(1-methyl-2-oxoindolin-6-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)piperidine-1-carboxylate 
• 1258324-52-5 (S)-tert-butyl 2-((S)-1-amino-3-(4-(3-(3-methoxypropyl)-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)piperidine-1-carboxylate 
• 1579996-61-4 (S)-N-((S)-1-cyano-2-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)ethyl)piperidine-2-carboxamide 
• 1579996-77-2 (S)-tert-butyl-2-((S)-1-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)-1-oxopropan-2-yl carbamoyl)piperidine-1-carboxylate 

Relevant articles and documents

Cathepsin C inhibitors: Property optimization and identification of a clinical candidate

A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.

PEPTIDYL NITRILES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE I INHIBITORS

The present invention provides compounds of formula (I) in which n, y, X1, X2, A, B, R1, R2, R3, R4 and R5 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use as dipeptidyl peptidase I (DPPI) inhibitors.