1162-64-7Relevant articles and documents
Asymmetric Total Synthesis and Biological Evaluation of (+)-Cycloclavine
McCabe, Stephanie R.,Wipf, Peter
, p. 213 - 224 (2019)
The first total synthesis of natural (+)-cycloclavine uses a catalytic asymmetric cyclopropanation of allene, a regiospecific Pd-catalyzed enone formation, and two intramolecular Diels-Alder reactions for indole/indoline annulations. The binding properties of natural (+)- and unnatural (-)-cycloclavine on 16 CNS receptors revealed significant stereospecificity and unique binding profiles in comparison to LSD, psilocin, and DMT. Differential 5-HT affinities, as well as novel sigma1 receptor properties bode well for potential therapeutic developments of clavine alkaloid scaffolds.
Benzoannellated Fenestranes Bearing para-Terphenyl Units
Seifert, Monika,Barth, Dieter,Kuck, Dietmar
, p. 6435 - 6449 (2021/11/30)
The synthesis of several centrotriindanes bearing ortho-phenyl groups in the sterically constricted bay regions is described. The classical three-step sequence including twofold cyclodehydration of the corresponding 2,2-dibenzyl-1,3-indanediols afforded a
(2,1-a)-Indenofluorene derivatives: Syntheses, X-ray structures, optical and electrochemical properties
Thirion, Damien,Poriel, Cyril,Rault-Berthelot, Joelle,Barriere, Frederic,Jeannin, Olivier
supporting information; experimental part, p. 13646 - 13658 (2011/02/27)
Two novel fluorophores based on the (2,1-a)-indenofluorenyl backbone, dispiro[fluorene-9,11'-indeno[2,1-a]fluorene-12',9''-fluorene], (2,1-a)-DSF-IF and 11,12-dihydroindeno[2,1-a]fluorene (2,1-a)-IF have been prepared through original and efficient synthe
