116220-89-4

Basic information

• Product Name: N^α-9-Fluorenylmethyloxycarbonyl-N^G-2,4,6-triisopropylbenzenesulphonyl-L-arginine
• CAS NO: 116220-89-4
• Molecular Weight: 662.85
• Mol File: 116220-89-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N^α-9-Fluorenylmethyloxycarbonyl-N^G-2,4,6-triisopropylbenzenesulphonyl-L-arginine(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-9-Fluorenylmethyloxycarbonyl-N^G-2,4,6-triisopropylbenzenesulphonyl-L-arginine(116220-89-4)
• EPA Substance Registry System: N^α-9-Fluorenylmethyloxycarbonyl-N^G-2,4,6-triisopropylbenzenesulphonyl-L-arginine(116220-89-4)

Safety Data

• Hazardous Substances Data: 116220-89-4(Hazardous Substances Data)

Upstream product

• 717-74-8 1,3,5-triisopropyl benzene 
• 6553-96-4 2,4,6-triisopropylphenylsulfonyl chloride 
• 58810-07-4 N^α-Benzyloxycarbonyl-N^G-2,4,6-triisopropylbenzenesulphonyl-L-arginine 
• 1234-35-1 Z-Arg-OH 
• 74-79-3 L-arginine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 91000-69-0 Fmoc-L-Arg-OH 

Relevant articles and documents

Factors Influencing the Acid Lability of Substituted Arylsulphonyl Arginine Protecting Groups

The kinetics of hydrolysis of new, NG-protected 2,4,6-triisopropylbenzene-sulphonyl (6), 4-methoxy-3,5-di-tert-butylbenzenesulphonyl (12) and phenanthrene-3-sulphonyl (17) Fmoc derivatives of L-arginine (1) in comparison with commercially available Fmoc-Arg(Mtr)-OH (Mtr = 4-methoxy-2,3,6-trimethyl-benzenesulphonyl (2)) are studied.The acid lability of the arylsulphonyl group is decreasing as follows Mtr > Tip > Mtbs > Phen.The effect of electron-donating alkyl groups as substituents in increasing the acid lability of the arylsulphonyl residue seems to be in the order of methyl > isopropyl > tert-butyl, while the effect of extended delocalization does not appreciably increase the acid lability. - Keywords: 2,4,6-Triisopropylbenzenesulphonyl (Tip), 4-methoxy-3,5-di-tert-butylbenzenesulphonyl (Mtbs), Phenanthrene-3-sulphonyl (Phen) Residues