1162645-90-0

Basic information

• Product Name: C₃₀H₂₆N₆O₈
• Synonyms: C₃₀H₂₆N₆O₈
• CAS NO: 1162645-90-0
• Molecular Weight: 598.572
• Mol File: 1162645-90-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₆N₆O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₆N₆O₈(1162645-90-0)
• EPA Substance Registry System: C₃₀H₂₆N₆O₈(1162645-90-0)

Safety Data

• Hazardous Substances Data: 1162645-90-0(Hazardous Substances Data)

Upstream product

• 59157-06-1 4H,9H-diimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione-1,6-dicarboxylic dichloride 
• 5557-81-3 L-alanine benzyl ester hydrochloride 

Downstream Products

• 1135690-43-5 C₃₀H₄₃N₅O₈ 
• 1217318-17-6 C₂₂H₂₉N₅O₆ 

Relevant articles and documents

Parallel synthesis of an oligomeric imidazole-4, 5-dicarboxamide library

A library of oligomeric compounds was synthesized based on the imidazole-4, 5-dicarboxylic acid scaffold along with amino acid esters and chiral diamines derived from amino acids. The final compounds incorporate nonpolar amino acids (Leu, Phe, Trp), polar amino acids (Ser, Asp, Arg), and neutral amino acids (Gly, Ala), and were designed to be useful in screening for inhibitors of protein-protein interactions. Many of the protected and deprotected oligomers show evidence of conformational isomers persistent at room temperature in aqueous solution. A total of 317 final oligomers, out of 441 targeted compounds, were obtained in high analytical purity and of sufficient quantity to submit them for high-throughput screening as part of the NIH Roadmap.

Parallel synthesis of an imidazole-4,5-dicarboxamide library bearing amino acid esters and alkanamines

The imidazole-4,5-dicarboxylic acid scaffold is readily derivatized with amino acid esters and alkanamines to afford compounds with intramolecularly hydrogen bonded conformations that mimic substituted purines and therefore are hypothesized to be potential inhibitors of kinases through competitive binding to the ATP site. In this work, a total of 126 dissymmetrically disubstituted imidazole-4,5-dicarboxamides with amino acid ester and alkanamide substituents were prepared by parallel synthesis. The library members were purified by column chromatography on silica gel and the purified compounds characterized by LC-MS with LC detection at 214 nm. A selection of the final compounds was also analyzed by 1H-NMR spectroscopy. The analytically pure final products have been submitted to the Molecular Library Small Molecule Repository (MLSMR) for screening in the Molecular Library Screening Center Network (MLSCN) as part of the NIH Roadmap.