116296-30-1

Basic information

• Product Name: (5-ACETYL-2-METHOXYPHENYL)ACETIC ACID
• Synonyms: 5-acetyl-2-methoxyBenzeneacetic acid;Benzeneacetic acid, 5-acetyl-2-methoxy-
• CAS NO: 116296-30-1
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.21
• Mol File: 116296-30-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 402.9°C at 760 mmHg
• Flash Point: 160.1°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 3.24E-07mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: (5-ACETYL-2-METHOXYPHENYL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (5-ACETYL-2-METHOXYPHENYL)ACETIC ACID(116296-30-1)
• EPA Substance Registry System: (5-ACETYL-2-METHOXYPHENYL)ACETIC ACID(116296-30-1)

Safety Data

• Hazardous Substances Data: 116296-30-1(Hazardous Substances Data)

Usage

General Description

(5-ACETYL-2-METHOXYPHENYL)ACETIC ACID is a chemical compound with the molecular formula C10H10O4. It is also known by the name ACEMETACIN and is commonly used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of pain, inflammation, and fever. The compound works by inhibiting the production of prostaglandins, which are chemical messengers responsible for promoting inflammation, pain, and fever in the body. The acetylation of the compound enhances its anti-inflammatory activity and makes it a more potent analgesic. It is typically administered orally in tablet form and has been found to be effective in the management of conditions such as osteoarthritis, rheumatoid arthritis, and musculoskeletal pain. However, like other NSAIDs, (5-ACETYL-2-METHOXYPHENYL)ACETIC ACID may also have potential side effects and contraindications, and should be used under the guidance of a healthcare professional.

InChI:InChI=1/C11H12O4/c1-7(12)8-3-4-10(15-2)9(5-8)6-11(13)14/h3-5H,6H2,1-2H3,(H,13,14)

Upstream product

• 403499-85-4 (5-acetyl-2-methoxy-phenyl)-acetonitrile 
• 24085-05-0 1-(3-chloromethyl-4-hydroxyphenyl)ethanone 
• 62581-82-2 1-[3-(chloromethyl)-4-methoxyphenyl]-1-ethanone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 99-93-4 4-Hydroxyacetophenone 
• 93-25-4 2-methoxyphenylacetic acid 
• 6056-23-1 ethyl (2-methoxyphenyl)acetate 

Downstream Products

• 858453-61-9 1-methoxy-2,4-bis-(2-morpholino-2-oxo-ethyl)-benzene 
• 90844-05-6 (5-carboxy-2-methoxy-phenyl)-acetic acid 
• 81720-88-9 2-methoxy-5-hydroxyphenylacetic acid 
• 81720-89-0 (5-acetyl-2-hydroxyphenyl)acetic acid 
• 451-13-8 homogentisic acid 

Relevant articles and documents

Novel synthesis of benzofuran- and indol-2-yl-methanamine derivatives

We report on a novel synthesis towards benzofuran-2-yl-methanamine and indol-2-yl-methanamine derivatives by using ortho-methoxy and ortho-nitro substituted phenylacetic acids as starting material, respectively. For each compound series, a key intermediate bearing the oxazole-4-carboxylic acid methylester moiety was produced. Refluxing the ortho-methoxy series in HBr/HAc produced the desired benzofuran-2-yl-methanamines. Accordingly, for the synthesis of indoles the nitro-group was first reduced and refluxing these intermediates in HCl gave the corresponding indol-2-yl-methanamines. The method worked well with electron donating substituents. Limitations regarding electron withdrawing substituents are discussed. This straightforward synthetic procedure can be a useful approach to generate a variety of substituted benzofuran-2-yl-methanamine and indol-2-yl-methanamine compounds by starting from readily available phenylacetic acid derivatives.

Gamma-ketoacid dipeptides as inhibitors of caspase-3

This invention encompasses the novel compounds of Formula I, which are useful in the treatment of caspase-3 mediated diseases. The invention also encompasses certain pharmaceutical compositions comprising compounds of Formula I as well as methods for treatment of caspase-3 mediated diseases.