116325-35-0 Usage
Derivative of
Indole
Contains functional groups
Carbonitrile group and phenylsulfonyl group
Versatility
Building block in organic synthesis
Potential applications
Pharmaceutical and agrochemical industries
Reactivity
Useful for creating new chemical entities with diverse biological activities
Structure
Attracts synthetic chemists for developing novel molecules
Synthetic potential
Further research could lead to new drugs and valuable organic compounds
Chemical properties
Aromaticity, reactivity with nucleophiles and electrophiles, and stability due to resonance
Physical properties
Likely to be a solid at room temperature, with a melting point that can be determined experimentally
Solubility
Soluble in organic solvents such as dichloromethane, ethyl acetate, and acetone
Synthesis
Can be synthesized through various methods, such as the reaction between an indole derivative and a phenylsulfonyl chloride
Purity
Typically characterized by techniques like thin-layer chromatography (TLC), nuclear magnetic resonance (NMR), and mass spectrometry (MS)
Stability
Stable under normal laboratory conditions, but sensitive to strong acids, bases, or nucleophiles that could potentially react with the functional groups
Safety
Handle with care, as it may have potential hazards depending on its reactivity and biological activity. Appropriate safety measures should be taken during synthesis and handling.
Check Digit Verification of cas no
The CAS Registry Mumber 116325-35-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,3,2 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 116325-35:
(8*1)+(7*1)+(6*6)+(5*3)+(4*2)+(3*5)+(2*3)+(1*5)=100
100 % 10 = 0
So 116325-35-0 is a valid CAS Registry Number.
116325-35-0Relevant articles and documents
Manganese(III)-mediated oxidative radical addition of malonates to 2-cyanoindoles
Lopchuk, Justin M.,Montgomery, William L.,Jasinski, Jerry P.,Gorjifard, Sayeh,Gribble, Gordon W.
, p. 6142 - 6145 (2013/10/22)
2-Cyanoindole and N-methyl-2-cyanoindole undergo manganese(III)-mediated radical addition with activated methylene and methine compounds. Products of the methylene addition underwent additional oxidation during the course of the reaction to furnish the corresponding acetoxy compounds. Several structures were confirmed by X-ray crystallography.
Synthesis of heteroarenecarbonitriles by electrophilic cyanation; Reaction of metalated heteroarenes with p-toluenesulfonyl cyanide
Nagasaki, Izuru,Suzuki, Yumiko,Iwamoto, Ken-Ichi,Higashino, Takeo,Miyashita, Akira
, p. 443 - 450 (2007/10/03)
Several heteroarenecarbonitriles (5) were synthesized in moderate yields from heteroarenes (3) through metalation, followed by electrophilic cyanation using p-toluenesulfonyl cyanide. Similarly, trimethylsilylheteroarenes (8) were converted to heteroarenecarbonitriles (5) in good yields by treatment with p-toluenesulfonyl cyanide.
