116496-46-9

Basic information

• Product Name: 2-bromo-N-methyl-N-phenylbutanamide
• Synonyms: 2-bromo-N-methyl-N-phenylbutanamide
• CAS NO: 116496-46-9
• Molecular Weight: 256.142
• Mol File: 116496-46-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-methyl-N-phenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-methyl-N-phenylbutanamide(116496-46-9)
• EPA Substance Registry System: 2-bromo-N-methyl-N-phenylbutanamide(116496-46-9)

Safety Data

• Hazardous Substances Data: 116496-46-9(Hazardous Substances Data)

Upstream product

• 26074-52-2 2-bromo-butyryl bromide 
• 100-61-8 N-methylaniline 
• 22118-12-3 2-bromobutanoyl chloride 

Downstream Products

• 2525-35-1 3-ethyl-1-methyl-1,3-dihydro-2H-indol-2-one 

Relevant articles and documents

NiH-Catalyzed Remote Asymmetric Hydroalkylation of Alkenes with Racemic α-Bromo Amides

Reported here is a terminal-selective, remote asymmetric hydroalkylation of olefins with racemic α-bromo amides. The reaction proceeds by NiH-catalyzed alkene isomerization and subsequent alkylation reaction, and can enantioconvergently introduce an unsymmetrical secondary alkyl group from a racemic α-bromo amide onto a terminal C(sp3)?H position along the hydrocarbon chain of the alkene. This mild process affords a range of structurally diverse chiral α-alkylalkanoic amides in excellent yields, and high regio- and enantioselectivities. In addition, the synthetic utility of this protocol is further highlighted by the regioconvergent conversion of industrial raw materials of isomeric olefin mixtures into enantioriched α-alkylalkanoic amides on large scale.