116565-03-8

Basic information

• Product Name: N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester
• Synonyms: N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester
• CAS NO: 116565-03-8
• Molecular Weight: 309.362
• Mol File: 116565-03-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester(116565-03-8)
• EPA Substance Registry System: N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester(116565-03-8)

Safety Data

• Hazardous Substances Data: 116565-03-8(Hazardous Substances Data)

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 148692-40-4 methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 67-56-1 methanol 
• 72155-45-4 Boc-L-phenylalaninal 
• 191849-93-1 3(S)-(N-tert-butoxycarbonylamino)-2(R,S)-hydroxy-4-phenylbutyric acid 
• 74-88-4 methyl iodide 
• 186393-18-0 ((S)-1-benzyl-2-cyano-2-hydroxy-ethyl)-carbamic acid tert-butyl ester 
• 209173-80-8 2(RS)-hydroxy-3(S)-amino-4-phenylbutanoic acid 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 223763-80-2 (2S,3S)-AHPA-L-Leu-OH trifluoroacetic acid salt 
• 145986-90-9 N-Boc-(2S,3S)-AHPA-L-Leu-tert-butyl ester 
• 1055029-06-5 3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-propionic acid tert-butyl ester 
• 1054684-42-2 ((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-acetic acid tert-butyl ester 
• 145986-89-6 (S)-2-((S)-3-Amino-2-oxo-4-phenyl-butyrylamino)-4-methyl-pentanoic acid; compound with trifluoro-acetic acid 
• 62023-65-8 (2S,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutanoic acid 
• 139069-60-6 (3S,2S)-3-amino-2-hydroxy-4-phenylbutyric acid methyl ester 

Relevant articles and documents

Synthesis of macrocyclic α-ketoamide as a selective and reversible immunoproteasome inhibitor

In recent years, the human immunoproteasome has emerged as an attractive therapeutic target for various diseases, leading to a growing interest in the discovery of immunoproteasome inhibitors that selectively target specific subunits. Herein we report the design, synthesis, and evaluation of a new immunoproteasome inhibitor that feature a macrocyclic ring containing an internal α-ketoamide warhead. This compound is a selective and reversible inhibitor of immunoproteasome subunits β1i and β5i and shows essentially no inhibition of constitutive proteasome subunits. [Figure not available: see fulltext.]

Process for reducing α-amino ketones

The present invention has its objects to provide a method for reducing α-aminoketone derivatives under mild conditions with high stereoselectivity. This invention is a method for reducing α-aminoketone which comprises reacting an a-aminoketone derivative of general formula (1) with a compound prepared from an organoaluminum compound of general formula (4), a sulfonic acid derivative of general formula (5), and an alcohol compound of general formula (6) to give an α-aminoalcohol derivative of general formula (7)

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

Leukotriene A4 hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B4 is an inflammatory mediator, it is of interest to develop selective inh