1165800-97-4

Basic information

• Product Name: (3R,4R)-4-(2,4-Difluorophenyl)-3-Methyl-4-(1H-1,2,4-triazol-1-ylMethyl)-2-oxetanone
• Synonyms: (3R,4R)-4-(2,4-Difluorophenyl)-3-Methyl-4-(1H-1,2,4-triazol-1-ylMethyl)-2-oxetanone
• CAS NO: 1165800-97-4
• Molecular Formula: C₁₃H₁₁F₂N₃O₂
• Molecular Weight: 279.2421464
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1165800-97-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Ethyl Acetate
• CAS DataBase Reference: (3R,4R)-4-(2,4-Difluorophenyl)-3-Methyl-4-(1H-1,2,4-triazol-1-ylMethyl)-2-oxetanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-4-(2,4-Difluorophenyl)-3-Methyl-4-(1H-1,2,4-triazol-1-ylMethyl)-2-oxetanone(1165800-97-4)
• EPA Substance Registry System: (3R,4R)-4-(2,4-Difluorophenyl)-3-Methyl-4-(1H-1,2,4-triazol-1-ylMethyl)-2-oxetanone(1165800-97-4)

Safety Data

• Hazardous Substances Data: 1165800-97-4(Hazardous Substances Data)

Usage

Chemical Properties

Yello Syrup

Uses

Intermediate in the preparation of Ravuconazole (R128000).

Upstream product

• 166948-49-8 (2R,3R)-3-[3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-3-(1H-1,2,4-triazol-1-yl)]butanoic acid 

Relevant articles and documents

Improved chiral synthesis of ravuconazole

A short, elegant, and high yielding synthesis of ravoconazole is presented. The key step of this synthesis is an enantioselective palladium-catalyzed chiral zinc-allene addition reaction. The starting materials are 2-chloro-1-(2,4-difluorophenyl)-ethanone and (R)-4-phenylbutyn-2-ol obtained from enzymatic resolution of its racemate. Copyright Taylor & Francis Group, LLC.