116586-94-8Relevant articles and documents
A novel and convenient synthesis of (Z)-3,3,3-trifluoropropenyl alkyl ethers and CF3-substituted propyl acetals as versatile CF3-containing building blocks
Hong, Feng,Hu, Chang-Ming
, p. 57 - 58 (1996)
A novel and convenient preparation of (Z)-3,3,3-trifluoropropyl alkyl ethers and their further transformation into CF3-substituted propyl acetals is described.
Atom-economical synthesis of 3,3,3-trifluoropropanal dialkyl acetals through Pd/C catalyzed acetalization of 3,3,3-trifluoropropene
Kang, Jian-Ping,Lu, Ju-You,Li, Yang,Wang, Zhi-Xuan,Mao, Wei,Lu, Jian
, p. 39387 - 39391 (2016/06/01)
A facile and efficient procedure for one-step synthesis of 3,3,3-trifluoropropanal dialkyl acetals from readily available 3,3,3-trifluoropropene (TFP) has been developed. The catalyst can be recycled for 4 times without obvious deactivation. This process provides a novel and atom-economical synthetic strategy for the preparation of functional CF3-containing compounds.
Convenient synthesis of 3,3,3-trifluoropropanoic acid by hydrolytic oxidation of 3,3,3-trifluoropropanal dimethyl acetal
Komata, Takeo,Akiba, Shinya,Hosoi, Kenji,Ogura, Katsuyuki
, p. 35 - 39 (2008/03/11)
A convenient and efficient method for preparing 3,3,3-trifluoropropanoic acid (1) is reported. The starting material is 1-chloro-3,3,3-trifluoropropene (2) that can be easily transformed into 3,3,3-trifluoropropanal dimethyl acetal (4) on treatment with methanol and KOH followed by acid-catalyzed addition of methanol. Direct transformation of 4 into 1 was efficiently achieved with 30% aqueous hydrogen peroxide (4.0 equiv.) in the presence of FeCl3 (0.025 equiv.) and hydrochloric acid (0.5 equiv.).