1167430-59-2Relevant articles and documents
Facile synthesis of 1-aryl-2,3-dihydro-1H-isoindoles by cyclization of N-formyliminium ion via geometrically disfavored 5-ENDO-trig process
Kitabatake, Michikazu,Saitoh, Toshiaki,Sano, Takehiro,Horiguchi, Yoshie
scheme or table, p. 1177 - 1181 (2009/11/30)
Synthesis of l-aryl-2,3-dihydro-1H-isoindoles (isoindolines) (10) was achieved in a highly effective manner via acid catalyzed cyclization of N-foimyliminium ion (8) obtained from 2,3-dimethoxybenzylamine and carbonyl compounds with acetic-formic anhydride under a one pot procedure. This Pictet-Spengler type reaction provides a convenient method for preparing 1-arylisoindolines.