1167438-99-4Relevant articles and documents
Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitors via [3+2]-cycloaddition chemistry
Diner, Peter,Andersson, Terese,Kjellen, Jimmy,Elbing, Karin,Hohmann, Stefan,Grotli, Morten
experimental part, p. 1010 - 1016 (2010/08/21)
A series of 4,5-substituted 1,2,3-triazoles was synthesised via Cu(i)-catalysed azide-alkyne 1,3-dipolar [2+3]-cycloaddition reactions followed by a Suzuki coupling. The 1,2,3-triazoles were evaluated as inhibitors of the p38α MAP kinase, showing IC5