116835-82-6

Basic information

• Product Name: 2-Propenoic acid, 3-(4-methoxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2Z)-
• CAS NO: 116835-82-6
• Molecular Formula: C19H19NO5
• Molecular Weight: 341.364
• Mol File: 116835-82-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(4-methoxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(4-methoxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2Z)-(116835-82-6)
• EPA Substance Registry System: 2-Propenoic acid, 3-(4-methoxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2Z)-(116835-82-6)

Safety Data

• Hazardous Substances Data: 116835-82-6(Hazardous Substances Data)

Upstream product

• 100945-15-1 N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 114684-69-4 methyl 2-(benzyloxycarbonylamino)-2-(diethyloxyphosphoryl)acetate 

Downstream Products

• 116835-87-1 (Z)-Cbz-ΔTyr(Me)-OH 

Relevant articles and documents

CHEMICAL COMPOUNDS

The invention provides a new method for treating disorders associated with activation of the Notch signal transduction pathway comprising administering an effective amount of a compound of Formula (I), in free form or in a pharmaceutically acceptable salt

Convenient preparative method for synthesis of methyl (Z)-3-aryl-2-(carbobenzoxyamino)acrylates by Wittig-Horner reaction with the use of Et3N as a base

The Wittig-Horner reaction of CbzNHCH(CO2Me)P(O)(OMe)2 (1) with ArCHO (2) in the presence of Et3N as a base affords methyl (Z)-3-aryl-2-(carbobenzoxyamino)acrylates (3) with high degrees of diastereoselectivity (Z)/(E) > 10:1.One recrystallization of the crude product is sufficient to obtain isomerically and chemically pure (Z)-3. - Keywords: α,β-dehydro-α-amino acids; Wittig-Horner reaction; diastereoselectivity; triethylamine; (Z)-3-aryl-2-(carbobenzoxyamino)acrylates; synthesis.